"目录号: HY-14286
Autophagy-
Levosimendan(OR1259)是钙增敏剂，通过与cardiac troponin C (cTnC)结合而发挥作用。
Autophagy
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生物活性
Description
Levosimendan(OR1259) is a calcium sensitiser used in the management of acutely decompensated congestive heart failure.Target: OthersLevosimendan is a calcium sensitiser used in the management of acutely decompensated congestive heart failure. Levosimendan is an inodilator indicated for the short-term treatment of acutely decompensated severe chronic heart failure, and in situations where conventional therapy is not considered adequate. Levosimendan has shown preliminary positive effects in a range of conditions requiring inotropic support, including right ventricular failure, cardiogenic shock, septic shock, and Takotsubo cardiomyopathy [1]. The cardiovascular effects of levosimendan are exerted via more than an isolated drug-receptor interaction, and involve favorable energetic and neurohormonal changes that are unique in comparison to other types of inodilators [2]. Levosimendan might reduce mortality in cardiac surgery and cardiology settings of adult patients [3].
Clinical Trial
NCT02972918
Hospital Universitario de Canarias-Orion Corporation, Orion Pharma
Ventricular Dysfunction, Left-Hip Fracture
May 2014
NCT01969071
Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital
Mitral Valve Stenosis With Incompetence or Regurgitation
July 2009
Phase 4
NCT01120106
Bambino Gesù Hospital and Research Institute
Low Cardiac Output Syndrome
January 2009
Phase 2
NCT00988806
Hospital Universitario de Canarias
Advanced Heart Failure
November 2009
Phase 4
NCT01318460
AHEPA University Hospital-Orion Corporation, Orion Pharma
Coronary Artery Disease
March 2011
Phase 4
NCT03022877
RWTH Aachen University
Myocardial Infarction-Outcome
June 2017
NCT01720030
VieCuri Medical Centre-Orion Corporation, Orion Pharma
Acute Kidney Injury
September 2016
Phase 2-Phase 3
NCT01065194
Medical University Innsbruck-Orion Corporation, Orion Pharma
Chronic Stable Heart Failure
August 2009
Phase 3
NCT02531724
Sahlgrenska University Hospital, Sweden
Acute Kidney Injury-Renal Insufficiency, Acute
September 2015
Phase 4
NCT01536132
Parc de Salut Mar
Heart Failure
April 2010
Phase 4
NCT01221116
Ullevaal University Hospital
Heart Failure-Cardiac Surgery
January 2003
NCT01721434
University Medical Center Nijmegen-Orion Corporation, Orion Pharma
Muscle Weakness Conditions-Weaning Failure
September 2012
Phase 2-Phase 3
NCT01290146
Niguarda Hospital-Orion Corporation, Orion Pharma
Advanced Chronic Heart Failure
February 2011
Phase 3
NCT01210976
Tampere University Hospital
Heart Valve Disease
January 2009
Phase 4
NCT00154115
Kuopio University Hospital
Heart Failure
March 2005
Phase 4
NCT02640846
Sahlgrenska University Hospital, Sweden
Septic Shock-Cardiomyopathy
December 2015
Phase 4
NCT01301313
Jose Luis Vazquez Martinez-Hospital Universitario Ramon y Cajal
Acute Heart Failure
February 2011
Phase 2
NCT02133105
Göteborg University-Sahlgrenska University Hospital, Sweden
Cardiorenal Syndrome
April 2014
Phase 3
NCT00994825
Università Vita-Salute San Raffaele
Low Cardiac Output Syndrome
November 2009
Phase 4
NCT02025621
Tenax Therapeutics, Inc.
Coronary Artery Bypass Grafting-Mitral Valve Surgery-Low Cardiac Output Syndrome
July 2014
Phase 3
NCT01188369
University of Aarhus
Diastolic Dysfunction-Left Ventricular Hypertrophy
September 2010
Phase 4
NCT00800306
University of Roma La Sapienza
Septic Shock
November 2007
Phase 2
NCT02261948
Centro Cardiologico Monzino-Orion Corporation, Orion Pharma
Heart Failure
September 2012
Phase 4
NCT01022983
Sykehuset i Vestfold HF-Orion Corporation, Orion Pharma
Heart Failure-Hip Fracture
April 2011
Phase 4
NCT02184819
Assistance Publique - Hôpitaux de Paris-Ministry of Health, France
Coronary Artery Bypass Grafting-Left Ventricular Dysfonction
June 2013
Phase 3
NCT01101620
University Medical Center Nijmegen-Orion Corporation, Orion Pharma
Respiratory Muscle Function
April 2010
NCT00130871
Orion Corporation, Orion Pharma
Coronary Heart Disease
January 2004
Phase 2
NCT02973620
Tenax Therapeutics, Inc.
Heart Decompensation
NCT01595737
Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Cardiac Surgery
February 2011
Phase 4
NCT02232399
Göteborg University-Helsinki University Central Hospital
Congenital Heart Defects
October 2014
Phase 2
NCT01500785
Tampere University Hospital
Myocardial Stunning
January 2012
Phase 4
NCT02963454
Military Hospital of Tunis
Septic Shock
January 2011
NCT00130884
Orion Corporation, Orion Pharma
Chronic Heart Failure-Heart Diseases
March 2005
Phase 2
NCT00585104
University of Utah
Heart Failure
September 2006
Phase 2
NCT00324766
Oslo University Hospital
Myocardial Infarction-Heart Failure-Cardiogenic Shock
June 2006
Phase 4
NCT00698763
Orion Corporation, Orion Pharma
Transient Ischemic Attack-Stroke
August 2008
Phase 2
NCT00166127
Emory University-Abbott
Heart Failure
May 2005
Phase 3
NCT00610350
University of Roma La Sapienza-University College London Hospitals
Myocardial Protection
January 2005
Phase 4
NCT00048425
Abbott-Orion Corporation, Orion Pharma
Heart Failure, Congestive
September 2002
Phase 3
NCT02012946
Azienda Policlinico Umberto I
Cardiovascular Diseases
December 2013
Phase 4
NCT00527059
University of Roma La Sapienza
Heart Failure-Renal Insufficiency
October 2007
Phase 4
NCT00093301
Wentworth Area Health Services-Abbott
Cardiogenic Shock-Septic Shock
October 2004
Phase 2-Phase 3
NCT00549107
Ludwig Boltzmann Gesellschaft
Low Cardiac Output Syndrome
September 2007
Phase 2
NCT02275013
Charite University, Berlin, Germany
Treatment of Left Heart Insufficiency in an Operative Setting of Cardiac Surgery
January 2006
NCT00348504
Abbott-Orion Corporation, Orion Pharma
Acute Heart Failure
March 2003
Phase 3
NCT00695929
Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Congenital Cardiovascular Defects-Low Cardiac Output Syndrome
July 2008
NCT03189901
Qilu Hospital of Shandong University
Early Management-Acute Heart Failure-NSTEMI - Non-ST Segment Elevation MI
July 1, 2017
Phase 4
NCT01616069
Federal University of Juiz de Fora-Universidade Federal do Rio de Janeiro-National Institute of Cardiology/Ministry of Health
Cardiopulmonary Bypass Graft
February 2012
Phase 4