【妇产科.2019】基于硫辛酸、棕榈酰氨基乙酰胺和没药的天然整合剂在治疗慢性盆腔疼痛和子宫内膜异位症中的作用

文献DOI：10.23736/S0026-4784.19.04384-3

文献PMID：30696240

文献原文链接：https://sci-hub.se/10.23736/S0026-4784.19.04384-3

Role of a natural integrator based on lipoic acid palmitoiletanolamide and myrrh in the treatment of chronic pelvic pain and endometiosis

基于硫辛酸、棕榈酰氨基乙酰胺和没药的天然整合剂在治疗慢性盆腔疼痛和子宫内膜异位症中的作用

文献摘要：

Dysmenorrhea and chronic pelvic pain occur in a significantly higher percentage in women with endometriosis; this benign condition has an incidence ranging from 5 to 10% in the general population, while 35% to 50% of infertile women are affected. Treatment of the symptoms demands integrated approaches with the use of anti-inflammatory substances or drugs and lifestyle changes, including attention to diet. The use of traditional anti-inflammatory drugs over the long term is not very successful because of the fear of side effects so they are almost always used with a short-term formula of 7-10 days when the woman's general condition becomes difficult to bear. In recent years, particular attention has been paid to natural substances with recognized anti-inflammatory activities that, associated with one another, are able to synergize individual actions. A nutraceutical containing substances capable of fighting chronic pelvic pain has recently been put on the market. The possible action mechanism derives from a synergy of action between alpha- lipoic acid, palmitoiletanolamide (PEA) and myrrh (Pelvinox, Laborest Italia srl), whose action is so effective that it is able to replace the use of anti-inflammatory drugs. The aim of the study was to evaluate the effect of these active ingredients in women with endometriosis and chronic pelvic pain. This multicenter study saw the recruitment of 60 women (divided between the three centers participating in the study, Siena, Bologna and Udine) aged between 20 and 39 suffering from endometriosis (ovarian) and chronic pelvic pain. All the women took one nutraceutical (Pelvinox, Laborest, MI) at a dose of two tablets per day for 6 months. The results showed a significant reduction in pain symptoms as regards dyspareunia, dysmenorrhea and chronic pelvic pain, while there was no change in the mean diameter of the endometriosis cysts. In light of the above, it is believed that substances such as alpha-lipoic acid, PEA and myrrh may play a very important role in this type of patient in the treatment of individual symptoms.

文献摘要：

子宫内膜异位症患者的痛经和慢性盆腔疼痛发生率明显较高，这种良性疾病的发病率在一般人群中为5％至10％，而35％至50％的不孕妇女受到影响。症状的治疗需要综合方法，使用抗炎物质或药物和改变生活方式，包括注意饮食。长期使用传统的抗炎药并不是很成功，因为担心副作用，因此当女性的一般状况难以承受时，它们几乎总是使用7-10天的短期配方。

近年来，特别注意具有公认的抗炎活性的天然物质，它们彼此相关，能够协同个体作用。最近，市场上出现了含有能够抵抗慢性骨盆疼痛的物质的营养保健品。可能的作用机制来自α-硫辛酸、棕榈酰基乙酰胺（PEA）和没药（Pelvinox，Laborest Italia srl）之间的作用协同作用，其作用非常有效，能够取代抗炎药物的使用。

该研究的目的是评估这些活性成分对子宫内膜异位症和慢性盆腔疼痛患者的影响。这项多中心研究发现，60名女性（分为参与该研究的三个中心，锡耶纳、博洛尼亚和乌迪内）的年龄在20至39岁之间，患有子宫内膜异位症（卵巢）和慢性盆腔疼痛。所有女性每天服用两片营养保健品（Pelvinox，Laborest，MI），持续6个月。结果显示，在性交困难、痛经和慢性盆腔疼痛方面疼痛症状显著减少，而子宫内膜异位囊肿的平均直径没有变化。鉴于上述情况，据信诸如α-硫辛酸、PEA和没药的物质在这类患者中可以在治疗个体症状中起非常重要的作用