Could not load file or assembly 'AjaxPro.2' or one of its dependencies. 拒绝访问

Could not load file or assembly 'AjaxPro.2' or one of its dependencies. 拒绝访问

郁闷啊。。怎么解决呢。。。
web.config里的配置如下：
<httpHandlers>
   
<remove verb="*" path="*.asmx"/>
<add verb="*" path="*.asmx" validate="false" type="System.Web.Script.Services.ScriptHandlerFactory, System.Web.Extensions, Version=1.0.61025.0, Culture=neutral, PublicKeyToken=31bf3856ad364e35"/>
<add verb="*" path="*_AppService.axd" validate="false" type="System.Web.Script.Services.ScriptHandlerFactory, System.Web.Extensions, Version=1.0.61025.0, Culture=neutral, PublicKeyToken=31bf3856ad364e35"/>
<add verb="GET,HEAD" path="ScriptResource.axd" type="System.Web.Handlers.ScriptResourceHandler, System.Web.Extensions, Version=1.0.61025.0, Culture=neutral, PublicKeyToken=31bf3856ad364e35" validate="false"/>
      <add verb="POST,GET" path="ajaxpro/*.ashx" type="AjaxPro.AjaxHandlerFactory, AjaxPro.2"/>
</httpHandlers>