【代谢.2019】α-硫辛酸会影响脂质分布吗？ 随机对照试验的荟萃分析和系统评价

文献DOI：10.1016/j.ejphar.2019.01.001

文献PMID：30633888

文献原文链接：http://doi.org.sci-hub.tw/10.1016/j.ejphar.2019.01.001

Does alpha-lipoic acid affect lipid profile? A meta-analysis and systematic review on randomized controlled trials.

α-硫辛酸会影响脂质谱分布吗？ 随机对照试验的荟萃分析和系统评价

【Abstract】

Randomized controlled trials (RCTs) have demonstrated that alpha lipoic acid (ALA) may change lipid profile, but their results are contradictory. The aim of this study is to conduct a meta-analysis to assess the effects of ALA on lipid profile. Electronic database including ISI web of science, Ovid, PubMed/Medline, SCOPUS, and Google Scholar were searched up to February 2018. RCTs which assessed ALA effects on lipid profile were selected. Weighted mean difference (WMD) and 95% confidence intervals (CIs) in serum lipids concentrations were defined as intervention effects. Random effects model was used to estimate the pooled effect. Heterogeneity was measured by using I2 test. The protocol was registered with PROSPERO (No. CRD42017072365). Database search retrieved 12 articles. Serum total cholesterol (TC) and low density lipoprotein-cholesterol (LDL-) levels were significantly lower in subjects supplemented with alpha-lipoic acid compared with controls (WMD=-10.18 mg/dL; 95% CI: -16.16, -4.20 mg/dL; P=0.001 and WMD=-9.22 mg/dL; 95% CI: -18.28, -0.16 mg/dL; P=0.001, respectively), but no significant changes were found for high density lipoprotein-cholesterol (HDL-c) (WMD: 3.02 mg/dL; 95% CI: -0.39, 6.43; P=0.082). The overall effect of ALA on serum triglyceride did not reveal any significant change, but in subgroup analysis based on health status (diabetic vs. non-diabetic), ALA decreased serum triglyceride levels in both diabetic and non-diabetic groups compared with controls. This meta-analysis revealed that ALA might favorably affect lipid profile especially LDL and TC. However, for confirming these results, more studies particularly among hyperlipidemic patients are needed.

Keywords: alpha lipoic acid, lipoprotein, lipids, cholesterol, triglyceride, meta-analysis

摘要翻译：

随机对照试验（RCTs）已经证明α硫辛酸（ALA）可能改变脂质谱，但这些研究结果是有矛盾的。本研究的目的是进行荟萃分析，以评估ALA对脂质谱的影响。搜索包括ISI科学网、Ovid、PubMed / Medline、SCOPUS和Google Scholar在内的电子数据库（至2018年2月）。选择评估ALA对脂质谱的影响的RCT。将血清脂质浓度的加权平均差（WMD）和95％置信区间（CI）定义为干预效应。随机效应模型用于估计汇总效应。通过使用I2测试来测量异质性。该协议已在PROSPERO（编号CRD42017072365）注册。数据库搜索检索了12篇文章与对照组相比，补充α-硫辛酸的受试者的血清总胆固醇（TC）和低密度脂蛋白胆固醇（LDL-）水平显著降低（WMD = -10.18 mg / dL; 95％CI：-16.16，-4.20 mg / dL; P = 0.001和WMD = -9.22 mg / dL; 95％CI：-18.28，-0.16 mg / dL; P = 0.001，但高密度脂蛋白胆固醇（HDL-）未发现显著变化）（WMD：3.02mg / dL; 95％CI：-0.39,6.43; P = 0.082）。 ALA对血清甘油三酯的总体影响未显示任何显著变化，但在基于健康状况（糖尿病与非糖尿病）的亚组分析中，与对照相比，ALA降低糖尿病组和非糖尿病组中的血清甘油三酯水平。该荟萃分析显示ALA可能有利地影响脂质特征，尤其是LDL和TC。然而，为了证实这些结果，需要更多的研究，尤其是高脂血症患者。

关键词：α硫辛酸，脂蛋白，脂类，胆固醇，甘油三酯，荟萃分析