文献DOI：10.1080/1028415X.2018.1554322
文献PMID：30526417
文献原文链接：http://doi.org.sci-hub.tw/10.1080/1028415X.2018.1554322
Immunomodulatory activities of alpha lipoic acid with a special focus on its efficacy in preventing miscarriage
α硫辛酸的免疫调节活性，聚焦预防流产的功效
Abstract
Introduction: Alpha lipoic acid (ALA) is an essential mitochondrial co-factor and, as a free molecule, it can exert multi-level immunomodulatory functions. Both ALA and its reduced form, dihydrolipoic acid (DHLA), are believed to be able to chelate heavy metals, to regenerate essential antioxidants and to repair important molecules damaged by oxidation. The largest part of the effects of ALA/DHLA couple can be explained by a specific stimulatory activity on Nrf2-dependent gene transcription and by the inhibition of NF-kB activity. These features have prompted its as a drug for several diseases.
Areas covered: This article surveys the main features of ALA/DHLA and its therapeutic effects. Its complex and differentiated function cannot simply be reduced to anti-inflammatory, antioxidant and detoxifying action. We highlight its capability to finely modulate several physiological pathways when unbalanced. In particular, we focus our attention on pregnancy, in relation to ALA administration by oral route and by a new formulation for vaginal delivery, in patients with threatened miscarriage.
Expert opinion: Future efforts should be devoted to explaining carefully ALA/DHLA mechanism of action to reactivate the physiological balance when modified during pregnancy. On the other hand, ALA safety in pregnant women and its pharmacokinetics by vaginal route, have to be studied in depth. Moreover, ALA efficacy has to be confirmed in a much larger sample of patients.
Keywords: Alpha-lipoic acid, antioxidant activity, drug delivery, gynecology, immunomodulation, inflammation, miscarriage, NF-kB, Nrf2, subchorionic hematoma, vaginal route.
摘要翻译：
简介：α-硫辛酸（ALA）是一种必需的线粒体辅助因子，作为一种游离分子，它可以发挥多级免疫调节功能。 ALA及其还原形式二氢硫辛酸（DHLA）被认为能够螯合重金属，再生必需的抗氧化剂并修复因氧化而受损的重要分子。 ALA / DHLA偶联作用的最大部分可以通过对Nrf2依赖性基因转录的特异性刺激活性和通过抑制NF-κB活性来解释。这些特征促使其成为治疗几种疾病的药物。
涵盖的领域：本文调查了ALA / DHLA的主要特征及其治疗效果。其复杂和分化的功能不能简单地局限在抗炎、抗氧化和解毒作用。我们强调它在不平衡时精细调节几种生理途径的能力。特别是，我们将注意力集中在怀孕上，与口服途径的ALA给药和阴道分娩的新配方相关，用于患有先兆流产的患者。
专家意见：未来的努力应该专注于解释ALA / DHLA的作用机制，以便在怀孕期间修正生理平衡。另一方面，必须深入研究孕妇的ALA安全性及其阴道途径的药代动力学。此外，ALA疗效必须在更大的患者样本中得到证实。
关键词：α-硫辛酸，抗氧化活性，给药，妇科，免疫调节，炎症，流产，NF-kB，Nrf2，subchorionic血肿，阴道途径。
