Mps1-IN-2

"目录号: HY-13994

Cell Cycle/DNA DamageCytoskeleton-

Mps1-IN-2是Mps1抑制剂，IC50为145 nM。

Mps1

相关产品

Mps1-IN-1-AZ3146-CFI-402257-BAY 1161909-BAY1217389-MPI-0479605-NMS-P715-Mps1-IN-3-

生物活性

Description

Mps1-IN-2 is a potent Mps1 kianse inhibitor with IC50 value of 145 nM. IC50 value: 145 nM [1]Target: Mps1Mps1-IN-2 inhibited Mps1 kinase activity with half-maximal inhibitory concentrations (IC50) of 3145 nM when screened at 1 μM ATP (apparent Km for ATP < 1 μM). Both compounds demonstrated greater than 1000-fold selectivity relative to the 352 member kinase panel with the major exceptions of Alk and Ltk for Mps1-IN-1 and Gak and Plk1 for Mps1-IN-2. The M602Q Mps1 mutant was 5 and 19-fold less sensitive to Mps1-IN-1 and Mps1-IN-2 respectively.

References

[1].Kwiatkowski N, et al. Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function. Nat Chem Biol. 2010 May;6(5):359-68.