MC 1046

"目录号: HY-15264

Vitamin D Related-

MC 1046(Impurity A of Calcipotriol)是钙泊三醇的杂质，钙泊三醇是1,25-Dihydroxyvitamin D3类似物。

VD/VDR

相关产品

Calcitriol-Calcipotriol-Maxacalcitol-Ercalcidiol-Alfacalcidol-Calcifediol monohydrate-Paricalcitol-Seocalcitol-Secalciferol-3-O-(2-Aminoethyl)-25-hydroxyvitamin D3-Ercalcitriol-Vitamin D4-Calcitetrol-Calcitriol Impurities A-Cholecalciferol-

生物活性

Description

MC 1046(Impurity A of Calcipotriol) is an impurity of Calcipotriol; Calcipotriol (MC 903; Calcipotriene) is a ligand of VDR-like receptors. IC50 value:Target: Vitamin D3 analog that displays minimal effects on calcium homeostasis. Regulates cell differentiation and proliferation; Calcipotriol (MC 903; Calcipotriene) exhibits antiproliferative activity against human HL-60, HL60/MX2, MCF-7, T47D, SCC-25 and mouse WEHI-3 cancer cell lines.

References

[1].Binderup (1993) Comparison of calcipotriol with selected metabolites and analogues of vitamin D3: effects on cell growth regulation in vitro and calcium metabolism in vivo. Pharmacol.Toxicol. 72 240.

[2].Knutson et al (1997) Pharmacokinetics and systemic effect on calcium homeostasis of 1a,24-dihydroxyvitamin D2 in rats. Biochem.Pharmacol. 53 829.

[3].Wietrzyk et al (2007) Antitumor properties of diastereomeric and geometric analogs of vitamin D3. Anticancer Drugs 18 447.111

[4].P.J. Marie, D. Connes, M. Hott, L. Miravet. Comparative effects of a novel Vitamin D Analogue MC-903 and 1,25-dihydroxyvitamin D3 on alkaline phosphatase activity, osteocalcin and DNA synthesis by human osteoblastic cells in culture. Bone. Volume 11, Issu