"目录号: HY-13634A
Metabolic Enzyme/Protease-
Ezatiostat 是一种 glutathione 类似物，为谷胱甘肽 S-转移酶 P1-1 (GSTP1-1) 抑制剂。
Gutathione S-transferase
相关产品
Ezatiostat hydrochloride-
生物活性
Description
Ezatiostat is a glutathione analog inhibitor ofglutathione S-transferase P1-1 (GSTP1-1).
In Vitro
Ezatiostat causes dissociation of the enzyme from the jun-N-terminal kinase/c-Jun (JNK/JUN) complex, leading to JNK activation by phosphorylation. The therapeutic action of ezatiostat appears to include both proliferation of normal myeloid progenitors as well as apoptosis of the malignant clone[1].
Clinical Trial
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Telik
Myelodysplastic Syndrome (MDS)
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Phase 2
NCT01459159
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Myelodysplastic Syndrome (MDS)
October 2011
Phase 2
NCT00909584
Telik
Severe Chronic Neutropenia
April 2009
Phase 2
NCT01062152
Telik
Myelodysplastic Syndrome
November 2009
Phase 1
NCT00701870
Telik
Non-small Cell Lung Cancer
October 2008
Phase 2
NCT00700206
Telik
Myelodysplastic Syndrome (MDS)
May 2008
Phase 2
NCT00280631
Telik
Myelodysplastic Syndrome (MDS)
February 2006
Phase 1-Phase 2
NCT00035867
Telik
Myelodysplastic Syndromes
April 2002
Phase 1-Phase 2
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References
[1].Galili N, et al. Prediction of response to therapy with ezatiostat in lower risk myelodysplastic syndrome. J Hematol Oncol. 2012 May 6;5:20.