"目录号: HY-15321
Immunology/Inflammation-
Etoricoxib(MK-0663)能选择性抑制COX-2，IC50为1.1μM（LPS诱导的前列腺素E2合成实验），而对COX-1的IC50则为116μM（凝血后血清血栓素B2生成实验）。
COX
相关产品
Celecoxib-Indomethacin-Acetaminophen-Paradol-Aspirin-Ibuprofen-NS-398-Rofecoxib-Diclofenac Sodium-Iguratimod-Parecoxib-Sulindac-Naproxen-Valdecoxib-(-)-Epicatechin-
生物活性
Description
Etoricoxib(MK-0663) selectively inhibited COX-2 in human whole blood assays in vitro, with an IC50 value of 1.1 ± 0.1 μM for COX-2 (LPS-induced prostaglandin E2 synthesis), compared with an IC50 value of 116 ± 8 μM for COX-1 (serum thromboxane B2 generation after clotting of the blood). IC50 value: 1.1 uM (LPS-induced prostaglandin E2 synthesis)Target: COX-2In summary, Etoricoxib represents a novel agent that selectively inhibits COX-2 with 106-fold selectivity in human whole blood assays in vitro and with the lowest potency of inhibition of COX-1 compared with other reported selective agents. Single preoperative oral dose (120 mg) of Etoricoxib, given one hour before surgery, has significantly reduced the post operative pain at rest and movement and improved sleep in patients undergoing single level diskectomy without any side effects and with good patient satisfaction.
Clinical Trial
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Ossification, Heterotopic
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Phase 4
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Osteoarthritis-Rheumatoid Arthritis-Ankylosing Spondylitis-Gout-Arthritis
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Rheumatoid Arthritis
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Phase 4
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Spanish Foundation of Rheumatology
Ankylosing Spondylitis
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NCT00757627
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Postherpetic Neuralgia-Neuralgia
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Phase 4
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Kuopio University Hospital
Pain, Postoperative
January 2013
Phase 4
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Pain
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Phase 1
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Merck Sharp & Dohme Corp.
Osteoarthritis of the Knee
March 2012
Phase 3
NCT00756873
University of Regensburg-Merck Sharp & Dohme Corp.
Tonsillectomy
October 2008
Phase 3
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Hartford Hospital-Shaare Zedek Medical Center
Headache-Fasting-Fasting Headache-Ramadan Headache
July 2010
Phase 4
NCT00755521
Meir Medical Center
Fibromyalgia
September 2008
Phase 4
NCT02149758
Tatyasaheb Kore Dental College
Cyclooxygenase Two Inhibitors-Etoricoxib-Periodontitis-Superoxide Dismutase-Saliva
January 2013
Phase 4
NCT01344720
Azienda Sanitaria Locale 4, Teramo
Low Back Pain
May 2011
Phase 4
NCT01088256
Ruhr University of Bochum
Causalgia-Polyneuropathy-Postherpetic Neuralgia-Peripheral Nerve Injury-Radiculopathy
February 2011
Phase 2
NCT00935116
Hospital Padre Hurtado
Acute Pain
July 2009
Phase 4
NCT00529594
University of Sao Paulo
Proliferative Diabetic Retinopathy
August 2006
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Merck Sharp & Dohme Corp.
Arthritis, Rheumatoid
September 2010
Phase 3
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Merck Sharp & Dohme Corp.
Osteoarthritis
October 2011
Phase 4
NCT02750917
Foisor Orthopedics Clinical Hospital
Postoperative Pain
September 2014
Phase 3
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Merck Sharp & Dohme Corp.
Acute Pain Following a Total Abdominal Hysterectomy
October 2008
Phase 3
NCT02534610
Foisor Orthopedics Clinical Hospital
Postoperative Pain
January 2014
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Merck Sharp & Dohme Corp.
Pain, Postoperative
December 2008
Phase 3
NCT01619150
C4Pain-Merck Sharp & Dohme Corp.
Osteoarthritis
July 2012
Phase 2
NCT01208207
Merck Sharp & Dohme Corp.
Spondylitis, Ankylosing
September 2010
Phase 3
NCT00855777
Universita di Verona
Dental Extraction
April 2009
Phase 4
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Hospital Vozandez-Merck Sharp & Dohme Corp.
Laparoscopic Surgery for Appendicitis-Laparoscopic Surgery for Cholecystitis-Laparoscopic Surgery for Ovarian Cysts
April 2006
Phase 4
NCT00746720
University of Erlangen-Nürnberg Medical School-HELIOS Kliniken GmbH-Rush University Medical Center-Merck Sharp & Dohme Corp.
Pain-Osteoarthritis, Hip-Postoperative Pain
May 2006
Phase 2
NCT00799149
Meir Medical Center
Knee Arthroscopy
June 2006
Phase 4
NCT00440739
Mahidol University
Pain
September 2005
Phase 4
NCT00876317
Clinica Virgen Milagrosa-Merck Sharp & Dohme Corp.
Soft Tissue Injuries of the Shoulder-Tenosynovitis and Bursitis Affecting the Shoulder
November 2009
Phase 3
NCT01246362
Singapore General Hospital-Merck Sharp & Dohme Corp.
Knee Osteoarthritis
July 2011
Phase 2
NCT00763685
East Tallinn Central Hospital-Merck Sharp & Dohme Corp.
Pain
June 2010
Phase 4
NCT01327638
Merck Sharp & Dohme Corp.
Spondylarthropathies; Spondylitis, Ankylosing
February 15, 2011
NCT00927004
Curtin University-Merck Sharp & Dohme Corp.
Osteoarthritis-Pain
August 2010
Phase 4
NCT01271348
X-pert Med GmbH
Muscle Pain
January 2011
Phase 1
NCT00554346
National Taiwan University Hospital-Merck Sharp & Dohme Corp.
Post-operational Pain
May 2008
Phase 4
NCT01229774
University of Regensburg-Merck Sharp & Dohme Corp.
Coxarthrosis-Arthroplasties Hip Replacement-Perioperative Blood Loss
February 2011
Phase 3
NCT00954785
University of Cape Town-Merck Sharp & Dohme Corp.
Sprain
November 2009
Phase 4
NCT00250445
Merck Sharp & Dohme Corp.
Rheumatoid Arthritis,Osteoarthritis
January 2003
Phase 3
NCT00752921
Shaare Zedek Medical Center
Headache
September 2008
Phase 4
NCT00149253
Khon Kaen University
a Single-Dose of Etoricoxib-Post-Operative Morphine Consumption-Total Pain Relief Over 8 Hr(TOPAR8)-Post Transabdominal Hysterectomy
December 2004
Phase 3
NCT00142558
Merck Sharp & Dohme Corp.
Acute Gout
January 1, 2005
Phase 4
NCT00373464
Ullevaal University Hospital-Merck Sharp & Dohme Corp.-University of Oslo-Oslo University Hospital
Hysterectomy-Tubal Excision-Ovariectomy-Postoperative Pain
March 2006
Phase 3
NCT00140972
Merck Sharp & Dohme Corp.
Osteoarthritis
December 3, 2004
Phase 4
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Merck Sharp & Dohme Corp.
Dysmenorrhea
November 2011
Phase 3
NCT00793052
Tel-Aviv Sourasky Medical Center
Trismus-Edema-Pain
November 2008
NCT01077843
Merck Sharp & Dohme Corp.
Ankylosing Spondylitis
August 17, 2009
NCT00525993
Núcleo de Estudos em Esportes e Ortopedia, Brazil-Merck Sharp & Dohme Corp.
Sprains and Strains-Contusions
December 2008
Phase 4