???????????????????
????????????60?????????????????????????????????????[1]?2020?????????ADA?????????????????????[2]
??????????????????????????????
??????20%?30%???????????????????????????????????????????[3]
?????????????????????????????????????????????????????????????????????????????????
???????????????
??????????????
??????????????????????????????????[4]
??????????????????????????????????????????????????????????????????????
?????????????????????????????-1?GLP-1??????????????????????????????[4]
????????????????????????????????????????????
??????????????????????????????????
??2???????????
????????????????2018????????????????????????????????
??1
?????????????????????????????
??????????????????????????????????????????????
????
?????500~1000mg/??
1~2???????????2000mg/?????????
????
??500mg?1?2??
???????????????????1000mg?1?2??
??????????????????????1500~2000mg????????2~3?????????????????????????
??2
?????????
??????????????????????????????????????????????????????????????????????????
????????????????XR?????????????????????????????????????????????????????????????????GSD???????
?????????????????????????????
??????????????????????????????????
?????????????????????????????????????????????????
?????????????????????????????????????????????????????????????????50%????????75%?[5]
????????????????????????????????????????????????????????????
??3???????????
?????????????????????????????????????????2??????????????????????????????????????????????????????????????????????????????????????????????????????
??????????????????????10????????????????????????????[1]??????????????????
?????????????2?????????????????????
????????????????????????????????????????????????[6]
?????????????????????????????????????????????????
???????????????????????????????????????????????????????????????????????????????
??????????90%??10???????????[7]??????1???????????????????
??????????????????????????????XR???????????????????????????????
?????
?????
??????????????
????????????????????????????
??????????????????
????
1.???,???,???,?.????????????(2018??).???????, 2019, 027(003):161-173.
2.Delgado K, Chamberlain JJ, Shubrook JH, Skolnik N, Trujillo J. Pharmacologic Approaches to Glycemic Treatment of Type 2 Diabetes: Synopsis of the 2020 American Diabetes Association's Standards of Medical Care in Diabetes Clinical Guideline. Ann Intern Med, 2020 Sep 1.
3.Dujic T, Zhou K, Donnelly LA, Tavendale R, Palmer CN, Pearson ER.Association of Organic Cation Transporter 1 With Intolerance to Metformin inType 2 Diabetes: A GoDARTS Study. Diabetes. 2015;64(5):86-93.
4.LJ M, CJ B, ER P. Metformin and the gastrointestinal tract. Diabetologia. 2016;59(3):426-435.
5.Blonde L, Dailey GE, Jabbour SA, Reasner CA, Mills DJ. Gastrointestinal tolerability of extended-release metformin tablets compared to immediate-release metformin tablets: results of a retrospective cohort study. Current medical research and opinion. 2004;20(4):565-572.
6.???,???,???,?.??2????????(2017?).???????,2018,10(1):4-67.
7.???????????.????????????????????????????????????2020??4??P406.