最开始是想安装 Bioconductor 中的 minfi （ https://github.com/hansenlab/minfi ）这个 R 包，但是发现不管是 conda 还是 BiocManager::install("minfi") 总不能成功，依赖包贼多不说，有些依赖包还特别坑爹。
首先要说的是 sparseMatrixStats （ https://github.com/const-ae/sparseMatrixStats ），虽然这个包比较坑，但作者起码在 GitHub 上给出了说明和解决方法。
最坑的应该是一个叫 rhdf5filters （ https://github.com/grimbough/rhdf5filters ）的 R 包，费劲了九牛二虎之力都没搞好，尤其是在 GCC-4.8.5 编译器下有人说 " assume it is just obsolete compiler "，让我感觉到我的 CentOS-6.5 +gcc-4.8.5 想要安装好它基本是没戏了！
几经折腾，虽然最终在 R-3.4 中倒腾成功了，但是对于 R>=3.5 总是耿耿于怀想再尝试一下（不见棺材不落泪 ），结合到前几天看到的 devtoolset ，于是想着去折腾一下。
有时候现实就是这么残酷，摩拳擦掌蠢蠢欲试，有时候结果会让你直接吐血——在安装 devtoolset 的时候总发现有这么一条重复出现且让人讨厌的 openssl 错误信息：
** Found 1 pre-existing rpmdb problem(s), 'yum check' output follows:
openssl-1.0.1e-57.el6.x86_64 is a duplicate with openssl-1.0.1e-15.el6.x86_64
初生牛犊不怕虎（其实当时心里还是有点忐忑的 ），一怒之下，就把重复的 openssl-1.0.1e-57.el6.x86_64 卸载了！！！
$ rpm -e openssl-1.0.1e-57.el6.x86_64
-
yum 不能用了，开始提示 libssl.so.10 不存在！
libssl.so.10: cannot open shared object file: No such file or directory
-
新的 Terminal 想要通过 SSH 再次登陆 log01，提示网络被关闭，登陆不上去了！！
开始意识到出问题了，于是去谷歌（搜索完差点一口老血喷出来！）！问题还挺严重性（心跳已经快飚到 180 了 ）！！但万幸的是 root 还没有退出来！！！
于是开始自救！
首先，下载对应版本的 rpm（这时候 wget/scp 都罢工了！），上传到服务器，然后 rpm 安装。
最先下载的是 openssl-1.0.0-27.el6.src.rpm，但 rpm 安装的时候又出现了新的问题。
[root@log01 lib64]# rpm -ivh /home/bioadmin/openssl-1.0.0-27.el6.src.rpm
warning: /home/bioadmin/openssl-1.0.0-27.el6.src.rpm: Header V3 RSA/SHA256 Signature, key ID fd431d51: NOKEY
1:openssl warning: user mockbuild does not exist - using root
warning: group mockbuild does not exist - using root
warning: user mockbuild does not exist - using root
warning: group mockbuild does not exist - using root
......
warning: group mockbuild does not exist - using root
########################################### [100%]
warning: user mockbuild does not exist - using root
warning: group mockbuild does not exist - using root
warning: user mockbuild does not exist - using root
warning: group mockbuild does not exist - using root
[root@log01 lib64]# sudo useradd -s /sbin/nologin mockbuild
[root@log01 lib64]# rpm -ivh /RiboBio/home/bi.chengnan/R/openssl-1.0.0-27.el6.src.rpm
warning: /RiboBio/home/bi.chengnan/R/openssl-1.0.0-27.el6.src.rpm: Header V3 RSA/SHA256 Signature, key ID fd431d51: NOKEY
1:openssl ########################################### [100%]
安装完，发现不起作用， /usr/lib64 下面缺失的 libssl.so.10 和 libcrypto.so.10 没有回来，SSH 依然无法登陆。
接着，下载卸载的 openssl-1.0.1e-57.el6.x86_64.rpm，不出意外 rpm 安装又遇到新的问题（心底一万个草泥马飘过）！
[root@log01 usr]# rpm -ivh /home/bioadmin/openssl-1.0.1e-57.el6.x86_64.rpm
warning: /home/bioadmin/openssl-1.0.1e-57.el6.x86_64.rpm: Header V3 RSA/SHA1 Signature, key ID c105b9de: NOKEY
Preparing... ########################################### [100%]
file /usr/bin/openssl from install of openssl-1.0.1e-57.el6.x86_64 conflicts with file from package openssl-1.0.1e-15.el6.x86_64
file /usr/lib64/.libcrypto.so.1.0.1e.hmac from install of openssl-1.0.1e-57.el6.x86_64 conflicts with file from package openssl-1.0.1e-15.el6.x86_64
file /usr/lib64/.libssl.so.1.0.1e.hmac from install of openssl-1.0.1e-57.el6.x86_64 conflicts with file from package openssl-1.0.1e-15.el6.x86_64
file /usr/lib64/libcrypto.so.1.0.1e from install of openssl-1.0.1e-57.el6.x86_64 conflicts with file from package openssl-1.0.1e-15.el6.x86_64
file /usr/lib64/libssl.so.1.0.1e from install of openssl-1.0.1e-57.el6.x86_64 conflicts with file from package openssl-1.0.1e-15.el6.x86_64
file /usr/lib64/openssl/engines/lib4758cca.so from install of openssl-1.0.1e-57.el6.x86_64 conflicts with file from package openssl-1.0.1e-15.el6.x86_64
file /usr/lib64/openssl/engines/libaep.so from install of openssl-1.0.1e-57.el6.x86_64 conflicts with file from package openssl-1.0.1e-15.el6.x86_64
file /usr/lib64/openssl/engines/libatalla.so from install of openssl-1.0.1e-57.el6.x86_64 conflicts with file from package openssl-1.0.1e-15.el6.x86_64
file /usr/lib64/openssl/engines/libcapi.so from install of openssl-1.0.1e-57.el6.x86_64 conflicts with file from package openssl-1.0.1e-15.el6.x86_64
file /usr/lib64/openssl/engines/libchil.so from install of openssl-1.0.1e-57.el6.x86_64 conflicts with file from package openssl-1.0.1e-15.el6.x86_64
file /usr/lib64/openssl/engines/libcswift.so from install of openssl-1.0.1e-57.el6.x86_64 conflicts with file from package openssl-1.0.1e-15.el6.x86_64
file /usr/lib64/openssl/engines/libgmp.so from install of openssl-1.0.1e-57.el6.x86_64 conflicts with file from package openssl-1.0.1e-15.el6.x86_64
file /usr/lib64/openssl/engines/libnuron.so from install of openssl-1.0.1e-57.el6.x86_64 conflicts with file from package openssl-1.0.1e-15.el6.x86_64
file /usr/lib64/openssl/engines/libpadlock.so from install of openssl-1.0.1e-57.el6.x86_64 conflicts with file from package openssl-1.0.1e-15.el6.x86_64
file /usr/lib64/openssl/engines/libsureware.so from install of openssl-1.0.1e-57.el6.x86_64 conflicts with file from package openssl-1.0.1e-15.el6.x86_64
file /usr/lib64/openssl/engines/libubsec.so from install of openssl-1.0.1e-57.el6.x86_64 conflicts with file from package openssl-1.0.1e-15.el6.x86_64
file /usr/share/doc/openssl-1.0.1e/README.FIPS from install of openssl-1.0.1e-57.el6.x86_64 conflicts with file from package openssl-1.0.1e-15.el6.x86_64
file /usr/share/man/man1/ca.1ssl.gz from install of openssl-1.0.1e-57.el6.x86_64 conflicts with file from package openssl-1.0.1e-15.el6.x86_64
file /usr/share/man/man1/ciphers.1ssl.gz from install of openssl-1.0.1e-57.el6.x86_64 conflicts with file from package openssl-1.0.1e-15.el6.x86_64
file /usr/share/man/man1/cms.1ssl.gz from install of openssl-1.0.1e-57.el6.x86_64 conflicts with file from package openssl-1.0.1e-15.el6.x86_64
file /usr/share/man/man1/ec.1ssl.gz from install of openssl-1.0.1e-57.el6.x86_64 conflicts with file from package openssl-1.0.1e-15.el6.x86_64
file /usr/share/man/man1/ocsp.1ssl.gz from install of openssl-1.0.1e-57.el6.x86_64 conflicts with file from package openssl-1.0.1e-15.el6.x86_64
file /usr/share/man/man1/openssl.1ssl.gz from install of openssl-1.0.1e-57.el6.x86_64 conflicts with file from package openssl-1.0.1e-15.el6.x86_64
file /usr/share/man/man1/req.1ssl.gz from install of openssl-1.0.1e-57.el6.x86_64 conflicts with file from package openssl-1.0.1e-15.el6.x86_64
file /usr/share/man/man1/s_client.1ssl.gz from install of openssl-1.0.1e-57.el6.x86_64 conflicts with file from package openssl-1.0.1e-15.el6.x86_64
file /usr/share/man/man1/s_server.1ssl.gz from install of openssl-1.0.1e-57.el6.x86_64 conflicts with file from package openssl-1.0.1e-15.el6.x86_64
file /usr/share/man/man1/s_time.1ssl.gz from install of openssl-1.0.1e-57.el6.x86_64 conflicts with file from package openssl-1.0.1e-15.el6.x86_64
file /usr/share/man/man1/smime.1ssl.gz from install of openssl-1.0.1e-57.el6.x86_64 conflicts with file from package openssl-1.0.1e-15.el6.x86_64
file /usr/share/man/man1/speed.1ssl.gz from install of openssl-1.0.1e-57.el6.x86_64 conflicts with file from package openssl-1.0.1e-15.el6.x86_64
file /usr/share/man/man1/ts.1ssl.gz from install of openssl-1.0.1e-57.el6.x86_64 conflicts with file from package openssl-1.0.1e-15.el6.x86_64
file /usr/share/man/man1/verify.1ssl.gz from install of openssl-1.0.1e-57.el6.x86_64 conflicts with file from package openssl-1.0.1e-15.el6.x86_64
file /usr/share/man/man1/x509.1ssl.gz from install of openssl-1.0.1e-57.el6.x86_64 conflicts with file from package openssl-1.0.1e-15.el6.x86_64
第三，尝试 openssl-1.0.1e-15.el6.x86_64.rpm，居然还是这个问题（。。。。。）！
[root@log01 usr]# rpm -ivh /home/bioadmin/openssl-1.0.1e-15.el6.x86_64.rpm
warning: /home/bioadmin/R/openssl-1.0.1e-15.el6.x86_64.rpm: Header V3 RSA/SHA1 Signature, key ID c105b9de: NOKEY
Preparing... ########################################### [100%]
package openssl-1.0.1e-15.el6.x86_64 is already installed
file /usr/bin/openssl from install of openssl-1.0.1e-15.el6.x86_64 conflicts with file from package openssl-1.0.1e-15.el6.x86_64
file /usr/lib64/.libcrypto.so.1.0.1e.hmac from install of openssl-1.0.1e-15.el6.x86_64 conflicts with file from package openssl-1.0.1e-15.el6.x86_64
file /usr/lib64/.libssl.so.1.0.1e.hmac from install of openssl-1.0.1e-15.el6.x86_64 conflicts with file from package openssl-1.0.1e-15.el6.x86_64
file /usr/lib64/libcrypto.so.1.0.1e from install of openssl-1.0.1e-15.el6.x86_64 conflicts with file from package openssl-1.0.1e-15.el6.x86_64
file /usr/lib64/libssl.so.1.0.1e from install of openssl-1.0.1e-15.el6.x86_64 conflicts with file from package openssl-1.0.1e-15.el6.x86_64
file /usr/lib64/openssl/engines/lib4758cca.so from install of openssl-1.0.1e-15.el6.x86_64 conflicts with file from package openssl-1.0.1e-15.el6.x86_64
file /usr/lib64/openssl/engines/libaep.so from install of openssl-1.0.1e-15.el6.x86_64 conflicts with file from package openssl-1.0.1e-15.el6.x86_64
file /usr/lib64/openssl/engines/libatalla.so from install of openssl-1.0.1e-15.el6.x86_64 conflicts with file from package openssl-1.0.1e-15.el6.x86_64
file /usr/lib64/openssl/engines/libcapi.so from install of openssl-1.0.1e-15.el6.x86_64 conflicts with file from package openssl-1.0.1e-15.el6.x86_64
file /usr/lib64/openssl/engines/libchil.so from install of openssl-1.0.1e-15.el6.x86_64 conflicts with file from package openssl-1.0.1e-15.el6.x86_64
file /usr/lib64/openssl/engines/libcswift.so from install of openssl-1.0.1e-15.el6.x86_64 conflicts with file from package openssl-1.0.1e-15.el6.x86_64
file /usr/lib64/openssl/engines/libgmp.so from install of openssl-1.0.1e-15.el6.x86_64 conflicts with file from package openssl-1.0.1e-15.el6.x86_64
file /usr/lib64/openssl/engines/libnuron.so from install of openssl-1.0.1e-15.el6.x86_64 conflicts with file from package openssl-1.0.1e-15.el6.x86_64
file /usr/lib64/openssl/engines/libpadlock.so from install of openssl-1.0.1e-15.el6.x86_64 conflicts with file from package openssl-1.0.1e-15.el6.x86_64
file /usr/lib64/openssl/engines/libsureware.so from install of openssl-1.0.1e-15.el6.x86_64 conflicts with file from package openssl-1.0.1e-15.el6.x86_64
file /usr/lib64/openssl/engines/libubsec.so from install of openssl-1.0.1e-15.el6.x86_64 conflicts with file from package openssl-1.0.1e-15.el6.x86_64
file /usr/share/man/man1/ca.1ssl.gz from install of openssl-1.0.1e-15.el6.x86_64 conflicts with file from package openssl-1.0.1e-15.el6.x86_64
file /usr/share/man/man1/cms.1ssl.gz from install of openssl-1.0.1e-15.el6.x86_64 conflicts with file from package openssl-1.0.1e-15.el6.x86_64
file /usr/share/man/man1/ec.1ssl.gz from install of openssl-1.0.1e-15.el6.x86_64 conflicts with file from package openssl-1.0.1e-15.el6.x86_64
file /usr/share/man/man1/ocsp.1ssl.gz from install of openssl-1.0.1e-15.el6.x86_64 conflicts with file from package openssl-1.0.1e-15.el6.x86_64
file /usr/share/man/man1/openssl.1ssl.gz from install of openssl-1.0.1e-15.el6.x86_64 conflicts with file from package openssl-1.0.1e-15.el6.x86_64
file /usr/share/man/man1/req.1ssl.gz from install of openssl-1.0.1e-15.el6.x86_64 conflicts with file from package openssl-1.0.1e-15.el6.x86_64
file /usr/share/man/man1/s_client.1ssl.gz from install of openssl-1.0.1e-15.el6.x86_64 conflicts with file from package openssl-1.0.1e-15.el6.x86_64
file /usr/share/man/man1/s_server.1ssl.gz from install of openssl-1.0.1e-15.el6.x86_64 conflicts with file from package openssl-1.0.1e-15.el6.x86_64
file /usr/share/man/man1/s_time.1ssl.gz from install of openssl-1.0.1e-15.el6.x86_64 conflicts with file from package openssl-1.0.1e-15.el6.x86_64
file /usr/share/man/man1/smime.1ssl.gz from install of openssl-1.0.1e-15.el6.x86_64 conflicts with file from package openssl-1.0.1e-15.el6.x86_64
file /usr/share/man/man1/ts.1ssl.gz from install of openssl-1.0.1e-15.el6.x86_64 conflicts with file from package openssl-1.0.1e-15.el6.x86_64
file /usr/share/man/man1/verify.1ssl.gz from install of openssl-1.0.1e-15.el6.x86_64 conflicts with file from package openssl-1.0.1e-15.el6.x86_64
file /usr/share/man/man1/x509.1ssl.gz from install of openssl-1.0.1e-15.el6.x86_64 conflicts with file from package openssl-1.0.1e-15.el6.x86_64
第四，尝试下载 openssl-1.0.1e.tar.gz 源码包安装，但是 make 的时候却出现了 Perl 有关的 Error（ 注意这里是一个很关键的步骤 ），最开始也以为要凉凉了！！
虽然在《 Centos6 卸载 OpenSSL 后重装提示 libssl.so.10: cannot open shared object file: No such file or directory 》这篇文章中提到：" Make：通过 make 来生成生成libssl.so.1.0.0 和 libcrypto.so.1.0.0 "，对这句话一直不理解以为是要安装完成后，在目标目录才会生成 libssl.so.1.0.0 和 libcrypto.so.1.0.0 ！其实并非如此！
$ tar zvxf openssl-1.0.1e.tar.gz
$ cd openssl-1.0.1e
$ ./config shared zlib-dynamic
$ make
......
installing man1/asn1parse.1
installing man1/CA.pl.1
installing man1/ca.1
installing man1/ciphers.1
installing man1/cms.1
cms.pod around line 457: Expected text after =item, not a number
cms.pod around line 461: Expected text after =item, not a number
cms.pod around line 465: Expected text after =item, not a number
cms.pod around line 470: Expected text after =item, not a number
cms.pod around line 474: Expected text after =item, not a number
POD document had syntax errors at /RiboBio/Bioinfo/APPS/perl/bin/pod2man line 71.
make: *** [install_docs] Error 1
其实， make 这一步已经在当前目录（注意是当前执行编译的目录）生成我们想要的 libssl.so.1.0.0 和 libcrypto.so.1.0.0 了 ！！！
第五，把这两个文件 ln -s 到 /usr/lib64 ，神奇的发现 yum 居然恢复正常了，虽然 SSH 还是不能登录。
[root@log01 lib64]# ln -s /home/bioadmin/src/openssl-1.0.1e/libssl.so.1.0.0 /usr/lib64/libssl.so.10
[root@log01 lib64]# ln -s /home/bioadmin/src/openssl-1.0.1e/libcrypto.so.1.0.0 /usr/lib64/libcrypto.so.10
最后，尝试着使用 yum 把 openssl 重新安装一下。这一次发现，一切都居然都恢复正常了！
GLIBC 升级安装与 SCL 知识盲区
2021-09-01
生信服务器 | 防火墙基本配置
2021-07-26
一次 HPC 病毒感染与解决经历
2020-10-30
生信服务器入门级基本设置
2020-06-05
在 Linux 上给用户赋予指定目录的读写权限
2019-10-05
Linux 下的动态库、静态库与环境变量
2019-09-07
本文分享自微信公众号 - 生信科技爱好者（bioitee）。
如有侵权，请联系 [email protected] 删除。
本文参与“ OSC源创计划 ”，欢迎正在阅读的你也加入，一起分享。