AZD0156

目录号: HY-100016

Cell Cycle/DNA DamagePI3K/Akt/mTOR|

AZD0156 是一种有效的,可口服的,选择性的ATM kinase抑制剂,常用于癌症治疗。

ATM/ATR

相关产品

Wortmannin|AZD6738|VE-822|VE-821|KU-55933|KU-60019|CP-466722|AZ20|CGK733|ETP-46464|HLM006474|BAY-1895344 hydrochloride|

生物活性

Description

AZD0156 is an orally active, potent and selectiveATM kinaseinhibitor, used for cancer treatment.

In Vitro

AZD0156 inhibits the kinase activity of ATM and ATM-mediated signaling, prevents DNA damage checkpoint activation, and disrupts DNA damage repair, inducs tumor cell apoptosis, and leads to cell death in ATM-overexpressing tumor cells[1].

Clinical Trial

NCT02588105

AstraZeneca|INC Research

Advanced Solid Tumours

November 10, 2015

Phase 1

NCT02588105

AstraZeneca|INC Research

Advanced Solid Tumours

November 10, 2015

Phase 1

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References

[1].Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer.?

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