目录号: HY-100016
Cell Cycle/DNA DamagePI3K/Akt/mTOR|
AZD0156 是一种有效的,可口服的,选择性的ATM kinase抑制剂,常用于癌症治疗。
ATM/ATR
相关产品
Wortmannin|AZD6738|VE-822|VE-821|KU-55933|KU-60019|CP-466722|AZ20|CGK733|ETP-46464|HLM006474|BAY-1895344 hydrochloride|
生物活性
Description
AZD0156 is an orally active, potent and selectiveATM kinaseinhibitor, used for cancer treatment.
In Vitro
AZD0156 inhibits the kinase activity of ATM and ATM-mediated signaling, prevents DNA damage checkpoint activation, and disrupts DNA damage repair, inducs tumor cell apoptosis, and leads to cell death in ATM-overexpressing tumor cells[1].
Clinical Trial
NCT02588105
AstraZeneca|INC Research
Advanced Solid Tumours
November 10, 2015
Phase 1
NCT02588105
AstraZeneca|INC Research
Advanced Solid Tumours
November 10, 2015
Phase 1
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References
[1].Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer.?