Pirarubicin

"目录号: HY-13725

Cell Cycle/DNA DamageAutophagy-

Pirarubicin是doxorubicin的类似物,为蒽环类化合物,具有抗肿瘤活性。

TopoisomeraseAutophagy

相关产品

Cycloheximide-TAK-242-LY294002-3-Methyladenine-(+)-JQ-1-SB 203580-SP600125-U0126-Enzalutamide-Actinomycin D-Olaparib-Doxorubicin hydrochloride-Dorsomorphin dihydrochloride-Mitomycin C-Bortezomib-

生物活性

Description

Pirarubicin is an analogue of the anthracycline anti-neoplastic doxorubicin, which is an inhibitor of Topo IITarget: TopoisomerasePirarubicin is an anthracycline drug. An analogue of the anthracycline antineoplastic antibiotic doxorubicin. Pirarubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. This agent is less cardiotoxic than doxorubicin and exhibits activity against some doxorubicin-resistant cell lines.

Clinical Trial

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Hebei Medical University Fourth Hospital

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Phase 4

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RenJi Hospital-Shanghai Pudong Hospital-Shanghai Pudong New Area Gongli Hospital

Intravesical Instillation

January 2017

Phase 2

NCT01249690

Second Military Medical University-Zhejiang University-Peking University People's Hospital-Fourth Military Medical University-Xiangya Hospital of Central South University-Institute of Hematology & Blood Diseases Hospital-Union hospital of Fujian Medical University-Harbin Hematology and Oncology Institute-First Affiliated Hospital, Sun Yat-Sen University-Beijing Jishuitan Hospital

Multiple Myeloma

June 2010

Phase 4

NCT02740426

Peking University First Hospital

Upper Tract Urothelial Carcinoma-Bladder Recurrence

August 2016

Phase 2

NCT02923557

Peking University First Hospital

Bladder Recurrence-Upper Tract Urothelial Carcinoma-Nephroureterectomy

November 2016

Phase 2

NCT02613026

307 Hospital of PLA

Breast Neoplasms

July 2009

Phase 3

NCT02547350

Xuesong Li-Peking University First Hospital

Upper Tract Urothelial Carcinoma-Bladder Recurrence

September 2015

Phase 2

NCT01746992

Ruijin Hospital

ALK-negative Anaplastic Large Cell Lymphoma-Peripherial T Cell Lymphoma,Not Otherwise Specified-Angioimmunoblastic T Cell Lymphoma-Enteropathy Associated T Cell Lymphoma-Hepatosplenic T Cell Lymphoma-Subcutaneous Panniculitis Like T Cell Lymphoma

September 2012

Phase 4

NCT02585479

Guangxi Medical University

Hepatocellular Carcinoma

October 2015

Phase 2-Phase 3

NCT02755311

Sun Yat-sen University

Hepatocellular Carcinoma

March 2014

Phase 3

NCT02301091

Ming Zhao-Sun Yat-sen University

Hepatocellular Carcinoma

October 2014

Phase 3

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Japan Adult Leukemia Study Group

Lymphoblastic Leukemia, Acute

September 2002

Phase 2

NCT01631383

University of Maryland-National Institute on Drug Abuse (NIDA)

Cocaine Use

October 2012

Phase 1

NCT02139761

University of Maryland-National Institute on Drug Abuse (NIDA)

Cocaine Use

September 2014

Phase 2

NCT02644902

Human Development Research Foundation, Pakistan-Duke University-University of Liverpool

Maternal Depression

March 2016

NCT02111915

University of Liverpool-National Institute of Mental Health (NIMH)-London School of Hygiene and Tropical Medicine

Unipolar Depression

October 2014

Phase 2-Phase 3

NCT02104232

London School of Hygiene and Tropical Medicine-National Institute of Mental Health (NIMH)-University of Liverpool

Unipolar Depression

October 2014

Phase 2-Phase 3

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References

[1].http://en.wikipedia.org/wiki/Pirarubicin

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