"目录号: HY-14855
Anti-infection-
Tedizolid 是一种新颖的恶唑烷酮，具有抗革兰氏阳性细菌的作用。
Bacterial
相关产品
G-418 disulfate-Anisomycin-Salinomycin-Avibactam sodium-Vancomycin hydrochloride-Hygromycin B-Bleomycin sulfate-Ciprofloxacin-Minocycline hydrochloride-Ampicillin sodium-Tetracycline hydrochloride-Tebipenem-Kanamycin sulfate-Solithromycin-Tunicamycin-
生物活性
Description
Tedizolid is a novel oxazolidinone with activity against Gram-positive pathogens.
In Vitro
Tedizolid (0.25 μg/mL) inhibits all 28 clinical isolates of PRSP, and is 4-fold more potent than linezolid against PRSP[1].
In Vivo
For mice infected with PSSP type III, the 100% survival rate is achieved with tedizolid phosphate at a minimum total daily dose of 10 mg/kg. Lungs of infected mice treated with tedizolid phosphate show less severe inflammation and edema, as indicated by the mean scores for inflammation and edema[1].
Clinical Trial
NCT03009045
Los Angeles Biomedical Research Institute
Bone and Joint Infection
February 6, 2017
Phase 2
NCT02342418
Amit.Pai-Merck Sharp & Dohme Corp.-Albany College of Pharmacy and Health Sciences
Obesity
March 2015
Phase 4
NCT02620787
Hartford Hospital-Merck Sharp & Dohme Corp.
Diabetes-Wound Infection-Healthy Volunteers
February 23, 2016
Phase 1
NCT03217565
Merck Sharp & Dohme Corp.
Gram-Positive Infections
March 5, 2018
Phase 1
NCT02444234
University of Southern California-Merck Sharp & Dohme Corp.
Cystic Fibrosis
July 2015
Phase 4
NCT02750761
Merck Sharp & Dohme Corp.
Gram-Positive Bacterial Infections
May 2, 2016
Phase 1
NCT02276482
Cubist Pharmaceuticals LLC
Skin Diseases, Infectious-Skin Diseases, Bacterial
March 25, 2015
Phase 3
NCT02991131
Bayer
Abscess-Cellulitis-Erysipelas-Wound Infection
January 13, 2017
NCT02066402
Bayer-Merck Sharp & Dohme Corp.
Bacterial Infections
March 4, 2014
Phase 3
NCT02019420
Cubist Pharmaceuticals LLC
Pneumonia
January 6, 2014
Phase 3
NCT02477514
Merck Sharp & Dohme Corp.
Skin Diseases, Bacterial
June 2015
Phase 1
NCT01967225
Bayer
Skin Diseases, Infectious
November 2013
Phase 3
NCT00666601
Trius Therapeutics LLC
Healthy
April 2008
Phase 1
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References
[1].Choi S, et al. Activity of Tedizolid Phosphate (TR-701) in Murine Models of Infection with Penicillin-resistant and Penicillin-sensitive Streptococcus pneumoniae. Antimicrob Agents Chemother. 2012 Jun 19.