"目录号: HY-15337
Autophagy-
Hesperidin (HP)是一个生物类黄酮，具有生物和药理属性是一种有效的抗氧化,抗炎,抗癌,与降脂降压代理活动。
Autophagy
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生物活性
Description
Hesperidin (HP) is a bioflavonoid that plays a role in plant defense and is abundant in citrus species, such as grapefruit, lemon and orange. Hesperidin is used effectively as a supplemental agent in complementary therapy protocols, since it possesses biological and pharmacological properties as an effective antioxidant, anti-inflammatory, anti-carcinogenic, and anti-hypertensive agent with lipid-lowering activity[1]IC50: hesperidin (IC50=116.68μmo/L))[4]in vitro: hesperidin and linarin are two of the main constituent of Valeriana's extract exhibiting a high affinity to KATP channel, which are related to the control of Ca++ concentration and release of GABA in synaptic nerve terminal, mainly on cells of SN[2]in vivo: Hesperidin was dissolved in 1% carboxymethyl cellulose (CMC) and administered orally at a dose of 50 mg/kg for 10 consecutive days. In the control group, rats were treated with the corn oil and 1% CMC vehicle.[1]
Clinical Trial
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University of Rome Tor Vergata
Endothelial Dysfunction-Metabolic Syndrome
November 2008
Phase 2
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University of Maryland
Obesity-Insulin Resistance
June 2015
Phase 2
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Nestlé-National University of Malaysia
Osteopenia-Osteoporosis
October 2007
Phase 2
NCT02610491
Maastricht University Medical Center
Metabolic Syndrome-Obesity
February 2015
Phase 2
NCT02927483
SunWave Pharma-Opera Contract Research Organization SRL
Chronic Venous Insufficiency
November 2016
Phase 3
NCT00330096
Nestlé-Institut National de la Recherche Agronomique-Centre de Recherche en Nutrition Humaine. Clermont-Ferrand, France
Osteoporosis, Osteopenia
March 2006
Phase 3
NCT01477281
Laboratório Teuto Brasileiro S/A
Chronic Venous Insufficiency-Disease
February 2012
Phase 3
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References
[1].Asli Cetin, Ali Otlu et al. Protective effect of hesperidin on oxidative and histological liver damage following carbon tetrachloride administration in Wistar rats. Arch Med Sci, 2016 Jun 1, 12(3): 486-493.
[2].Gesivaldo Santos, Bruno Andrade et al. SUR1 Receptor Interaction with Hesperidin and Linarin Predicts Possible Mechanisms of Action of Valeriana officinalis in Parkinson. Front Aging Neurosci, 2016, 8: 97.
[3].Jin Zhang, Jing Gao et al. Hesperidin inhibits HeLa cell proliferation through apoptosis mediated by endoplasmic reticulum stress pathways and cell cycle arrest. BMC Cancer, 2015, 15: 682.
[4].Cetin A, Otlu A, ea al. Protective effect of hesperidin on oxidative and histological liver damage following carbon tetrachlorideadministration in Wistar rats. Arch Med Sci, 2016 Jun 1, 12(3):486-93.