"目录号: HY-15284
GPCR/G Protein-
Prasugrel是ADP受体抑制剂，能通过不可逆的与P2Y12受体结合降低血小板的聚集。
P2Y Receptor
相关产品
Suramin sodium salt-Clopidogrel hydrogen sulfate-Ticagrelor-MRS 2578-AZD1283-N6-(4-Hydroxybenzyl)adenosine-Diquafosol tetrasodium-Prasugrel hydrochloride-Denufosol tetrasodium-
生物活性
Description
Prasugrel is a platelet inhibitor with IC50 value of 1.8 μM.IC50 value:Target: P2Y12 receptorPrasugrel is a novel platelet inhibitor used for the reduction of thrombotic cardiovascular events (including stent thrombosis) in patients with acute coronary syndrome who are to be managed with PCI. Prasugrel reduces the aggregation ("clumping") of platelets by irreversibly binding to P2Y12 receptors. In rat platelets, prasugrel AM inhibited in vitro platelet aggregation induced by ADP (10 μm) with an IC50 value of 1.8 μm. From Wikipedia
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Eli Lilly and Company-Daiichi Sankyo Inc.
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Phase 1
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University of Patras
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Phase 2
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Platelet Reactivity
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Deutsches Herzzentrum Muenchen
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Eli Lilly and Company-Daiichi Sankyo Inc.
Sickle Cell Anemia
July 2010
Phase 2
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University of Patras
Platelet Reactivity
October 2011
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Eli Lilly and Company-Daiichi Sankyo Inc.
Sickle Cell Disease
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Phase 3
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Phase 1
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Federal University of São Paulo
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July 2013
Phase 4
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Acute Coronary Syndrome-Unstable Angina
October 2014
Phase 3
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