"目录号: HY-13643
Epigenetics-
Daminozide(DMASA; DIMG; B 995)为植物生长调节剂，能选择性抑制KDM2/7 JmjC亚家族。
Histone Demethylase
相关产品
GSK-J4-GSK2879552-SP2509-Tranylcypromine hemisulfate-ORY-1001-JIB-04-ML324-IOX1-CPI-455-KDM5-IN-1-CBB1007-DDP-38003 dihydrochloride-KDM5A-IN-1-NCGC00244536-CBB1003-
生物活性
Description
Daminozide(DMASA; DIMG; B 995), a plant growth regulator, selectively inhibits the KDM2/7 JmjC subfamily.IC50 Value: Target: KDM2/7 JmjCInhibition of shoot elongation in dwarf and tall peas by the 1,1-dimethylhydrazide of succinic acid (B-995) was correlated with the inhibition of the oxidation of tryptamine-2-C(14) to indoleacetaldehyde-2-C(14) in homogenates prepared from epicotyls of young plants treated with B-995. The growth-retarding action of B-995 is attributed to the formation of 1,1-dimethylhydrazine in vivo. This hydrazine strongly inhibited tryptamine oxidation by pea epicotyl homogenates[1]. Daminozide (N-(dimethylamino)succinamic acid, 160 Da), a plant growth regulator, selectively inhibits the KDM2/7 JmjC subfamily[2].in vitro: Essential oil content increased with increasing levels of gibberellins and decreased when gibberellin biosynthesis was blocked withdaminozide. With increasing levels of gibberellins, 1,8-cineole and camphor contents increased. Daminozide blocked the accumulation of alpha- and beta-thujone.[3].in vivo:
References
[1].Rose NR, Woon EC, Tumber A, Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases. J Med Chem. 2012 Jul 26;55(14):6639-43.
[2].Schmiderer C, Grausgruber-Gr?ger S, Grassi P, Influence of gibberellin and daminozide on the expression of terpene synthases and on monoterpenes in common sage (Salvia officinalis). J Plant Physiol. 2010 Jul 1;167(10):779-86.
[3].Reed DJ, Moore TC, Anderson JD. Plant Growth Retardant B-995: A Possible Mode of Action. Science. 1965 Jun 11;148(3676):1469-71.