"目录号: HY-15341
Apoptosis-
BAM 7是Bax活化剂，EC50为3.3 μM。
Bcl-2 Family
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生物活性
Description
BAM 7 is a direct and selective activator of proapoptotic Bax with EC50 of 3.3 μM.IC50 Value: 3.3 uM(EC50) [1]Target: Bcl-2 Familyin vitro: BAM7 emerged as the most effective competitor, achieving an IC50 of 3.3 μM, which compared favorably with the IC50 of unlabeled BIM SAHB, considering that the molecule is only one-sixth the size of the BIM BH3 α-helical peptide. Co-incubation of BAM7 (10 μM, 20 μM, 30 μM and 40 μM) and monomeric BAX (5μM) induced dose- and time-responsive BAX oligomerization in solution, The combinations of BAX with ANA-BAM16 and BAXK21E with BAM7 had comparatively little to no effect even at the 1:8 dose ratio [1].in vivo: N/AClinical trial: N/A
References
[1].Gavathiotis E, Reyna DE, Bellairs JA, Direct and selective small-molecule activation of proapoptotic BAX. Nat Chem Biol. 2012 Jul;8(7):639-45.