Entecavir

"目录号: HY-13623

Anti-infection-

Entecavir(SQ 34676; BMS 200475)是有选择且有效地HBV抑制剂。在HepG2细胞中的EC50值为3.75 nM。

HBV

相关产品

Tenofovir Disoproxil Fumarate-Squalamine-Merimepodib-Entecavir monohydrate-Adefovir dipivoxil-Bay 41-4109-Clevudine-Bicyclol-Telbivudine-Osalmid-Helioxanthin 8-1-Helioxanthin derivative 5-4-2-Lagociclovir-Oxethazaine-

生物活性

Description

Entecavir (SQ 34676; BMS 200475) is a potent and selective inhibitor ofHBV, with anEC50of 3.75 nM in HepG2 cell.

IC50& Target

EC50: 3.75 nM (anti-HBV, HepG2 cell)[2]

In Vitro

BMS-200475 has a EC50of 3.75 nM against HBV. It is incorporated into the protein primer of HBV and subsequently inhibits the priming step of the reverse transcriptase. The antiviral activity of BMS-200475 is significantly less against the other RNA and DNA viruses[1]. Entecavir is more readily phosphorylated to its active metabolites than other deoxyguanosine analogs (penciclovir, ganciclovir, lobucavir, and aciclovir) or lamivudine. The intracellular half-life of entecavir is 15 h[2].

In Vivo

Daily oral treatment with BMS-200475 at doses ranging from 0.02 to 0.5 mg/kg of body weight for 1 to 3 months effectively reduces the level of woodchuck hepatitis virus (WHV) viremia in chronically infected woodchucks[3].

Clinical Trial

NCT01013272

The University of Hong Kong

Hepatitis B, Chronic

June 2007

NCT01046799

HepNet Study House, German Liverfoundation-Hannover Medical School

Liver Transplantation-Hepatitis B-Liver Disease

March 2008

Phase 3

NCT02777814

Sun Yat-sen University

Colorectal Neoplasms

May 2015

Phase 2

NCT02777801

Sun Yat-sen University

Stomach Neoplasms

June 2015

Phase 2

NCT01589952

Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh

Chronic Hepatitis B

March 2012

Phase 1-Phase 2

NCT00663182

Shanghai Changzheng Hospital

Hepatitis B Virus-Decompensated Cirrhosis

January 2008

Phase 4

NCT01768195

Peking University

Hepatitis B

January 2013

Phase 4

NCT01724723

National Taiwan University Hospital

Hepatitis-Tuberculosis-hepatitisB

December 2012

Phase 4

NCT01037062

Bristol-Myers Squibb

Chronic Hepatitis B

December 2003

Phase 2

NCT01243281

Chulalongkorn University

Chronic Hepatitis B

March 2011

NCT01627223

Taichung Veterans General Hospital-GlaxoSmithKline

Chronic Hepatitis B

July 2012

Phase 4

NCT01369199

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)-University of Pittsburgh

Hepatitis B

May 2012

Phase 3

NCT03062813

Guangdong General Hospital

Hepatitis B Virus Associated Nephrotic Syndrome

February 1, 2017

Phase 4

NCT01765231

Peking University

Hepatitis B

January 2013

Phase 4

NCT00926757

Taipei Veterans General Hospital, Taiwan-Bristol-Myers Squibb

Non Hodgkin's Lymphoma-Hepatitis B

April 2009

Phase 4

NCT00975091

Bristol-Myers Squibb

Chronic Hepatitis B Virus

May 2004

Phase 3

NCT01914744

Fudan University

Non-Hodgkin Lymphoma-Hepatitis B Reactivation

February 2013

Phase 2

NCT01368497

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Hepatitis B

September 2012

Phase 3

NCT01599130

Sun Yat-sen University

Hepatitis B

July 2012

NCT00704106

Pacific Health Foundation-Bristol-Myers Squibb

Hepatitis B

May 2008

NCT01354652

Asan Medical Center

Lactic Acidosis

May 2011

Phase 4

NCT01833611

National Cheng-Kung University Hospital

Chronic Hepatitis

September 2008

Phase 4

NCT01925820

National Taiwan University Hospital-Roche Pharma AG

Chronic Hepatitis B

January 2013

Phase 4

NCT00921180

National Taiwan University Hospital-National Science Council, Taiwan

Hepatitis B, Chronic

February 2007

Phase 4

NCT00625339

Yonsei University-Pusan National University Hospital

Hepatitis B, Chronic

February 2008

Phase 4

NCT00637663

Pusan National University Hospital-Yonsei University

Hepatitis B, Chronic

February 2008

Phase 4

NCT01639092

Asan Medical Center-Samsung Medical Center-Konkuk University Medical Center-Korea University Guro Hospital-Seoul National University Hospital

Chronic Viral Hepatitis B Without Delta-agent

September 2012

Phase 4

NCT01907230

Taipei Veterans General Hospital, Taiwan

Rheumatoid Arthritis-Hepatitis B Reactivation-Exposure to Hepatitis B Virus

July 2013

Phase 4

NCT00423891

Bristol-Myers Squibb

Hepatitis B, Chronic

June 30, 2007

Phase 1-Phase 2

NCT01711567

Korea University-Gilead Sciences

Chronic Hepatitis B

April 2013

Phase 4

NCT00718887

Bristol-Myers Squibb

Hepatitis B, Chronic

July 2008

Phase 4

NCT00625560

Yonsei University-Pusan National University Hospital

Hepatitis B, Chronic

February 2008

Phase 4

NCT01594905

Yonsei University-Bristol-Myers Squibb-Seoul St. Mary's Hospital-The Catholic University of Korea

Chronic Hepatitis B

August 2012

Phase 4

NCT01595685

Asan Medical Center

Chronic Viral Hepatitis B Without Delta-agent

May 2012

Phase 3

NCT00877760

Foundation for Liver Research

Chronic Hepatitis B

August 2009

Phase 4

NCT00395018

Bristol-Myers Squibb

Hepatitis B, Chronic

April 2007

Phase 3

NCT00597259

National Taiwan University Hospital-Bristol-Myers Squibb

Chronic Hepatitis B

January 2008

Phase 4

NCT01148576

Zhejiang University

Chronic Hepatitis B-Hepatic Steatosis

June 2010

Phase 4

NCT01079806

Bristol-Myers Squibb

Chronic Hepatitis B Virus, Pediatric

June 30, 2010

Phase 3

NCT02650271

Guangxi Medical University

Hepatocellular Carcinoma

July 2015

Phase 2-Phase 3

NCT02365402

Beijing Ditan Hospital

Chronic Hepatitis B

January 2013

Phase 4

NCT01254994

Sun Yat-sen University

Liver Failure

August 2007

Phase 2

NCT01323452

Foundation for Liver Research

Entecavir for Chronic Hepatitis B Patients

November 2010

NCT01023217

Asan Medical Center

Hepatitis B, Chronic

November 2009

Phase 4

NCT02241616

ShuGuang Hospital-Shanghai Zhongshan Hospital-Guangxi Ruikang Hospital-Hubei Hospital of Traditional Chinese Medicine-The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine-Huai'an No. 4 People's Hospital-Ruijin Hospital-Shenzhen Third People's Hospital-Beijing Ditan Hospital-Beijing YouAn Hospital-China-Japan Friendship Hospital-Tongji Hospital-Wenzhou Central Hospital-Jingmen No.1 People’s Hospital-Affiliated Hospital of Shandong Univercity of TCM-Guang'anmen Hospital of China Academy of Chinese Medical Sciences-The Ninth Hospital of Nanchang-The People's Hospital of Ningxia-Fifth Hospital of Shijiazhuang City-The Fifth People's Hospital of Suzhou-The Fifth People’s Hospital of Anyang

Hepatitis B Virus Related Cirrhosis

September 2014

Phase 4

NCT01326546

Chongqing Jiachen Biotechnology Ltd.-Third Military Medical University

Chronic Hepatitis B

June 2010

Phase 2

NCT00531167

Korea University-GlaxoSmithKline

Chronic Hepatitis B

April 2007

Phase 4

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