TCGA Pan-Cancer 中患者生存结果整合

文献来源

An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics

临床生存结局终点的定义

• Overall Survival (OS)

OS is the period from the date of diagnosis until the date of death from any cause. The censored time is from date of initial diagnosis until the date of last contact (largest number of days) from all the clinical data files (including both enrollment and follow-up forms). With minor exceptions as described in Handling of Special Cases and Problems in Clinical Data Files, derivation of OS outcomes was not problematic, as there exists minimal ambiguity in the databases about a patient’s status at different time points: alive or dead.

• Progression-Free Interval (PFI)

PFI is the period from the date of diagnosis until the date of the first occurrence of a new tumor event (NTE), which includes progression of the disease, locoregional recurrence, distant metastasis, new primary tumor, or death with tumor.

• Disease-Free Interval (DFI)

DFI is another commonly used surrogate signifying future cancer mortality in many clinical studies. DFI defined here is the period from the date of diagnosis (due to the reason given below) until the date of the first new tumor progression event subsequent to the determination of a patient’s disease-free status after their initial diagnosis and treatment.

• Disease-Specific Survival (DSS)

DSS defined here as death from the diagnosed cancer type, has much greater relevance to cancer biology and therapeutic impact. ADSS event is death from the disease, and the event time is from the date of initial diagnosis until the date of death from the disease.

详细推导请看原文献。

数据下载和生存分析可以使用我们的R包中生存分析模块

• github https://github.com/openbiox/UCSCXenaShiny

或者通过hiplot在线使用

• hiplot https://hiplot.com.cn/advance/ucsc-xena-shiny