缓激肽(Bradykinin) ELISA kit

灵敏可靠的ELISA试剂盒,用于检测血浆、血清和尿液样本中的缓激肽

缓激肽(Bradykinin)于1949年被发现,由血浆中的球蛋白前体在蛋白酶的作用下生成。它的名字表明它会促使肠道缓慢运动。早在1909年,人们就注意到在尿液中发现的物质(后来被确定为激肽)具有降压作用。激肽是血管舒张、血管通透性、NO 释放和花生四烯酸动员的效应物。它们是血压、肾功能和心脏功能的重要调节因子,并且还参与炎症反应。

缓激肽是通过血液中激肽释放酶系统的作用(与凝血级联有关)从血球蛋白激肽原HK 产生的,但也可以在其他组织和器官中产生。除激肽释放酶外,其他蛋白酶如纤溶酶也可释放缓激肽。几种肽酶可以降解激肽,包括血管紧张素转化酶(ACE),这是一种可将血管紧张素 I 转化为血管紧张素 II 并破坏缓激肽的金属蛋白酶。血浆缓激肽迅速降解为较小的稳定肽(BK1-5)形式。

Enzo Life Sciences的缓激肽(Bradykinin)ELISA试剂盒是一种竞争比色法免疫检测试剂盒,可在3小时内得出结果。欣博盛生物作为Enzo Life Sciences授权中国一级代理,可提供该产品,欢迎咨询。

产品特点

◆ 灵敏、可靠地检测低至 24.8 pg/ml 的缓激肽

◆ 仅需3小时即可得到多达 41 个样本(带复孔)的实验结果

◆ 动态范围宽,可轻松量化高表达水平和低表达水平的缓激肽

◆ 易于使用的液体颜色编码试剂,可减少错误

  

产品信息

产品货号

ADI-900-206

产品名称

Bradykinin ELISA kit(缓激肽ELISA试剂盒)/欣博盛生物

规格

96 wells

灵敏度

24.8 pg/ml

检测范围

11.7-30,000 pg/ml

应用

ELISA, Colorimetric detection

检测波长

450 nm

适用样本类型

血浆,血清和尿液样本

适用种属

不限种属

交叉反应

Bradykinin (100%) Lys-Bradykinin (Kallidin) (100%) 

and Les-des-Arg9-Bradykinin (<1%), BK1-5 stable degradion product (<0.1%)

使用/稳定性

Store all components at +4ºC, except Standard at -20ºC

运输温度

Blue Ice

短期保存温度

-20°C

长期保存温度

-20°C

试剂盒组分

Microtiter Plate, Conjugate, Antibody, Assay Buffer 16, Wash 

Buffer Concentrate, Standard, TMB Substrate, Stop Solution 2, Streptavidin-HRP

标准曲线示例

缓激肽(Bradykinin) ELISA kit_第1张图片

部分产品引用文献

Dysregulation of the kallikrein-kinin system in bronchoalveolar lavage fluid of patients with severe COVID-19: C.P. Martens, et al.; EBioMedicine 83, 104195 (2022)

Activation of angiotensin type 2 receptor attenuates testosterone-induced hypertension and uterine vascular resistance in pregnant rats: J.S. Mishra & S. Kumar; Biol. Reprod. 2021, ioab051 (2021)

gC1qR Antibody Can Modulate Endothelial Cell Permeability in Angioedema: M. Fandaros, et al.; Inflammation 1007, 10753 (2021)

Plasma contact factors as novel biomarkers for diagnosing Alzheimer's disease: J. Park, et al.; Biomark. Res. 9, 5 (2021)

The Expression of RAAS Key Receptors, Agtr2 and Bdkrb1, Is Downregulated at an Early Stage in a Rat Model of Wolfram Syndrome: M. Punapart, et al.; Genes (Basel) 12, 1717 (2021)

An antibody against HK blocks Alzheimer's disease peptide β-amyloid-induced bradykinin release in human plasma: Z.L. Chen, et al.; PNAS 116, 22921 (2019)

Serum bradykinin levels as a diagnostic marker in cervical cancer with a potential mechanism to promote VEGF expression via BDKRB2: Y. Zhou, et al.; Int. J. Oncol. 55, 131 (2019)

Post-translational modifications of eNOS augment nitric oxide availability and facilitates hypoxia adaptation in Ladakhi women: Pooja, et al.; Nitric Oxide 78, 103 (2018)

Protocols to assess coagulation following in vitro infection with hemorrhagic fever viruses: M.L. Tursiella, et al.; Methods Mol. Biol. 1604, 405 (2018)

Intestinal ischemic preconditioning ameliorates hepatic ischemia/reperfusion injury in rats: role of heme oxygenase 1 in the second window of protection: S. Kageyama, et al.; Liver Transpl. 21, 112 (2015)

Comparative effects of a novel angiotensin-converting enzyme inhibitor versus captopril on plasma angiotensins after myocardial infarction: J. Flores-Monroy, et al.; Pharmacology 94, 21 (2014)

High molecular weight kininogen binds phosphatidylserine and opsonizes urokinase plasminogen activator receptor-mediated efferocytosis: A. Yang, et al.; J. Immunol. 192, 4398 (2014)

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