No assembly found containing an OwinStartupAttribute

自从在ASP.NET MVC中使用NuGet添加SignalR类库之后，再次运行程序时，它出现了一个异常：

Server Error in '/' Application.

The following errors occurred while attempting to load the app.
- No assembly found containing an OwinStartupAttribute.
- No assembly found containing a Startup or [AssemblyName].Startup class.
To disable OWIN startup discovery, add the appSetting owin:AutomaticAppStartup with a value of "false" in your web.config.
To specify the OWIN startup Assembly, Class, or Method, add the appSetting owin:AppStartup with the fully qualified startup class or configuration method name in your web.config.

Description: An unhandled exception occurred during the execution of the current web request. Please review the stack trace for more information about the error and where it originated in the code.

Exception Details: System.EntryPointNotFoundException: The following errors occurred while attempting to load the app.
- No assembly found containing an OwinStartupAttribute.
- No assembly found containing a Startup or [AssemblyName].Startup class.
To disable OWIN startup discovery, add the appSetting owin:AutomaticAppStartup with a value of "false" in your web.config.
To specify the OWIN startup Assembly, Class, or Method, add the appSetting owin:AppStartup with the fully qualified startup class or configuration method name in your web.config.

Source Error:

An unhandled exception was generated during the execution of the current web request. Information regarding the origin and location of the exception can be identified using the exception stack trace below.

 在网上找到一些资料，解决方法，尝试下面步骤，在此备忘一下：