"目录号: HY-13750
Anti-infectionAutophagy-
Ebselen是HIV-1复制的小分子抑制剂, 是一种抗氧化药物。
HIVAutophagy
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生物活性
Description
Ebselen is a small-molecule capsid Inhibitor of HIV-1 replication.Target:Ebselen is an organoselenium compound, as an inhibitor of HIV-1 capsid CTD dimerization. Ebselen inhibits early viral postentry events of the HIV-1 life cycle by impairing the incoming capsid uncoating process. [1] Ebselen is a non-toxic seleno-organic drug with anti-inflammatory and antioxidant properties. Ebselen is an inhibitor of inositol monophosphatase (IMPase). Ebselen permeates the blood-brain barrier and inhibits endogenous inositol monophosphatase in mouse brain. [2]
Clinical Trial
NCT03013400
University of Oxford-Stanley Medical Research Institute-Sound Pharmaceuticals, Incorporated
Bipolar Disorder-Bipolar Disorder, Manic
June 30, 2017
Phase 2
NCT00762671
Brigham and Women's Hospital
Type 1 Diabetes Mellitus-Type 2 Diabetes Mellitus
May 1999
Phase 2-Phase 3
NCT02819856
Sound Pharmaceuticals, Incorporated-Medical University of South Carolina-Cystic Fibrosis Foundation Therapeutics
Ototoxicity
May 2017
Phase 1-Phase 2
NCT02603081
Sound Pharmaceuticals, Incorporated
Meniere's Disease
December 2015
Phase 1-Phase 2
NCT01452607
Sound Pharmaceuticals, Incorporated
Hearing Loss-Cancer
May 2006
Phase 1
NCT02779192
Sound Pharmaceuticals, Incorporated
Noise Induced Hearing Loss
September 2016
Phase 2
NCT01444846
Sound Pharmaceuticals, Incorporated-University of Florida
Temporary Auditory Threshold Shift
September 2011
Phase 2
NCT01451853
Sound Pharmaceuticals, Incorporated-VA Puget Sound Health Care System
Lung Cancer-Head and Neck Cancer-Hearing Loss-Ototoxicity-Tinnitus-Neuropathy
August 2016
Phase 2
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References
[1].Thenin-Houssier S, et al. Ebselen, a Small-Molecule Capsid Inhibitor of HIV-1 Replication. Antimicrob Agents Chemother. 2016 Mar 25;60(4):2195-208.
[2].Singh N, et al. A safe lithium mimetic for bipolar disorder. Nat Commun. 2013;4:1332. doi: 10.1038/ncomms2320.