文献积累（4）TF--SE--血管内皮特异性基因表达

The Transcription Factor ERG Regulates Super-Enhancers Associated with an Endothelial-Specific Gene Expression Program [Circulation Rearch]

GSEA

图片.png

转录因子绑定百分比

图片.png

SE区域乙酰化信号和TF绑定信号求相关

图片.png

展示SE相关特殊基因

图片.png

反向GSEA 用TF寻找SE

图片.png

Chipseeker 输入BED文件

图片.png

Chip-seq信号+Homer motif扫描

图片.png

Homer DiffBind 求差异峰定量 ；DiffBind出矩阵

图片.png

区域疾病突变富集 ERG super-enhancers prioritize cardiovascular disease variants. (A) Overlap of GWAS SNPs associated with disease trait classes within ERG defined SE (orange) with chromosome and size matched random SE (gray). Significance of enrichment was calculated by binomial distribution test with red dashed line indicating P = 0.05. Some points overlay. (B) Test for enrichment of selected CVD traitassociated SNPs within ERG defined SE (orange) with chromosome and size matched random SE (gray), as performed in A. Random region were restricted to open chromatin by excluding placement in repressed chromatin states in HUVEC

图片.png

TF chipseq数据；敲降数据；H3K27ac数据；