452 4.3.1 Insufficient system resources

About Exchange 2010 SP1 server, In my spamfilter queue have 200 emails. appear below error report:

452 4.3.1 Insufficient system resources (in reply to MAIL FROM command)

because of my Mail data's driver will be full. Only have 5GB. At least is left over 10% for all drivers size. I clear up the email logs, and then restart the microsoft transport service. the problem have fixed.

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