Haloperidol hydrochloride

"目录号: HY-14538A

GPCR/G ProteinNeuronal Signaling-

Haloperidol hydrochloride 是有效的dopamine D2 receptor拮抗剂,为一种安定药。

Dopamine Receptor

相关产品

Chlorpromazine hydrochloride-Brexpiprazole-Haloperidol-Cabergoline-Clozapine-Cariprazine hydrochloride-L-DOPA-Perphenazine-Dopamine hydrochloride-Oxidopamine hydrobromide-Sertindole-B-HT 920-Azaperone-Fluphenazine dihydrochloride-Iloperidone-

生物活性

Description

Haloperidol hydrochloride is a potentdopamine D2 receptorantagonist, widely used as an antipsychotic.

In Vivo

Haloperidol (1 mg) intra-arterially attenuates the dopamine-induced pancreatic secretion. Haloperidol (3 mg) completely inhibits the action of 10 μg of dopamine in the pancreas of the dogs[1]. Haloperidol (10 mg/kg) as well as chlorpromazine (CPZ, 15 mg/kg) blocks mescaline-induced altered behavior within 7 to 10 minutes when injected into the mice 45 minutes after 50 mg/kg (2 μc) of mescaline. Haloperidol has no effect on mescaline disappearance[2].

Clinical Trial

NCT01862302

McMaster University

Postoperative Confusion

August 2013

Phase 3

NCT01193621

Asan Medical Center-Seoul National University Hospital

Healthy

January 2008

Phase 1

NCT03110900

University of Arkansas-Mount Sinai Hospital, Chicago

Agitation,Psychomotor-Haloperidol Causing Adverse Effects in Therapeutic Use-Lorazepam Causing Adverse Effects in Therapeutic Use-Loxapine Causing Adverse Effects in Therapeutic Use

August 15, 2017

Phase 4

NCT01785290

Radboud University-ZonMw: The Netherlands Organisation for Health Research and Development

Delirium

June 2013

Phase 4

NCT02057549

The University of Texas Health Science Center, Houston

Gastroparesis

November 2012

Phase 4

NCT02103881

Minneapolis Medical Research Foundation

Agitation

April 2014

Phase 4

NCT00169091

Harvard Medical School-National Institute of Mental Health (NIMH)-Dartmouth-Hitchcock Medical Center-Commonwealth Research Center, Massachusetts-Novartis

Schizophrenia

March 1996

Phase 4

NCT00625014

Leiden University Medical Center-Dutch Diabetes Research Foundation

Insulin Resistance-Dyslipidemia

March 2005

NCT00947375

Central Mental Clinic for Outpatients of Baku City

Schizophrenia

January 2005

Phase 4

NCT01684969

Eric E. Prommer-Mayo Clinic

Nausea-Vomiting

March 2012

Early Phase 1

NCT03021486

M.D. Anderson Cancer Center-National Institutes of Health (NIH)

Malignant Neoplasms of Independent (Primary) Multiple Sites

June 5, 2017

Phase 2-Phase 3

NCT00753051

Khon Kaen University

Schizophrenia

June 2008

NCT03056482

Queen's University

Cannabis Use Disorder

May 21, 2017

Phase 4

NCT01750541

Shahid Beheshti University of Medical Sciences

Psychomotor Agitation

December 2012

Phase 3

NCT00797277

National Taiwan University Hospital-Yu-Li Hospital

Schizophrenia-Schizoaffective Disorder-Agitation

July 2006

Phase 3

NCT00954603

Chiang Mai University

Delirium

June 2009

Phase 3

NCT02972502

OhioHealth

Headache, Migraine

February 2014

Phase 4

NCT01174290

Northeastern University-National Institute on Aging (NIA)

Subsyndromal Delirium

September 2010

Phase 4

NCT01639599

The Catholic University of Korea

Gynecological Disease

March 2012

NCT00833300

Richard Hall-Dalhousie University-Nova Scotia Health Authority

Delirium-Agitation

June 2008

NCT03199950

Zuyderland Medisch Centrum

Delirium

June 23, 2017

Phase 4

NCT00505804

Austin Health-The Alfred

Delirium-Agitation-Ventilator Weaning-Respiration, Artificial-Intensive Care

January 2005

Phase 2

NCT00485901

Eli Lilly and Company

Schizophrenia

July 2004

Phase 3

NCT01501123

Catholic Health East

Agitation

November 2011

NCT01161277

Oslo University Hospital

Psychosis-Schizophrenia

August 2010

Phase 4

NCT00250237

Bronovo Hospital

Post-Operative Delirium-Hip Fracture

November 2005

Phase 3

NCT00859872

Central South University-Wuhan Mental Health Institute-Capital Medical University-Shanghai Mental Health Center-Guangzhou Mental Hospital-Chongqing Mental Hospital

Schizophrenia

August 2008

Phase 4

NCT00009217

New York State Psychiatric Institute-National Institute of Mental Health (NIMH)

Alzheimer's Disease-Psychosis-Agitation

January 1999

Phase 4

NCT00253110

Janssen, LP

Schizophrenia-Schizoaffective Disorder

May 1996

Phase 4

NCT01204255

Virginia Commonwealth University-National Cancer Institute (NCI)-American Cancer Society, Inc.

Healthy

November 2010

NCT01811459

Centre hospitalier de l'Université de Montréal (CHUM)-Fondation des pompiers du Québec pour les grands brûlés

Delirium

February 2013

Phase 3

NCT00429676

University of Colorado, Denver-Denver Health Medical Center

Delirium-Critical Illness

December 2005

Phase 2

NCT01530308

VU University Medical Center

Delirium

November 2012

Phase 4

NCT02909465

Tehran University of Medical Sciences

Ketamine Induced Agitation

July 2016

Phase 4

NCT01949662

M.D. Anderson Cancer Center-National Cancer Institute (NCI)

Advanced Cancers

January 2014

Phase 2

NCT00946491

Sandoz

Psychosis

April 1987

Phase 1

NCT01052389

Mario Negri Institute for Pharmacological Research-Bristol-Myers Squibb

Schizophrenia

July 2007

Phase 4

NCT00599287

UMC Utrecht

Delirium

February 2008

Phase 3

NCT02098499

United States Naval Medical Center, Portsmouth

Migraine Headaches-Nausea-Restlessness

June 2013

Phase 4

NCT00457366

University of Southern California-AstraZeneca

Agitation

May 2006

Phase 4

NCT02380118

The University of Hong Kong-Queen Mary Hospital, Hong Kong-Tuen Mun Hospital-Pamela Youde Nethersole Eastern Hospital-Ruttonjee Hospital-Prince of Wales Hospital, Shatin, Hong Kong

Acute Agitation, Behavioural Emergency

December 2014

Phase 4

NCT00300391

University of Pittsburgh-National Heart, Lung, and Blood Institute (NHLBI)

Delirium

March 2006

Phase 3

NCT00340379

Duke University-Pfizer-National Institute of Mental Health and Neuro Sciences, India

Affective Disorders

April 2003

Phase 2-Phase 3

NCT02143531

American University of Beirut Medical Center

Postoperative Nausea and Vomiting

September 2008

Phase 4

NCT00631722

Peking University

Schizophrenia

May 2007

NCT02747511

Western Michigan University School of Medicine

Headache-Migraine Disorders

October 2015

Phase 4

NCT00866645

Shanghai Mental Health Center-Shanghai Hotmed Sciences Co.,LTD

Agitation

February 2009

Phase 2-Phase 3

NCT03211897

Minneapolis Medical Research Foundation

Agitation,Psychomotor

June 15, 2017

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