参考链接:
http://lijunwei1228ok.blog.163.com/blog/static/9738379720140231713138/
import  sys
from  _winreg  import   *

#  tweak as necessary 
version  =  sys.version[: 3
installpath 
=  sys.prefix  
regpath 
=   " SOFTWARE\\Python\\Pythoncore\\%s\\ "   %  (version)
installkey 
=   " InstallPath "
pythonkey 
=   " PythonPath "
pythonpath 
=   " %s;%s\\Lib\\;%s\\DLLs\\ "   %  (
installpath, installpath, installpath
)

def  RegisterPy():
    
print   " begin RegisterPy  "
    
try :
        
print   " open key : %s " % regpath
        reg 
=  OpenKey(HKEY_CURRENT_USER, regpath)
    
except  EnvironmentError as e:    
        
try :           
            reg 
=  CreateKey(HKEY_CURRENT_USER, regpath) 
            SetValue(reg, installkey, REG_SZ, installpath) 
            SetValue(reg, pythonkey, REG_SZ, pythonpath)
            CloseKey(reg) 
        
except
            
print   " *** EXCEPT: Unable to register! "  
            
return              
        
        
print   " --- Python " , version,  " is now registered! "  
        
return

   
    
if  (QueryValue(reg, installkey)  ==  installpath  and  
        QueryValue(reg, pythonkey) 
==  pythonpath): 
            CloseKey(reg) 
            
print   " === Python " , version,  " is already registered! "  
            
return  CloseKey(reg) 

    
print   " *** ERROR:Unable to register! "  
    
print   " *** REASON:You probably have another Python installation! "

def  UnRegisterPy():
    
# print "begin UnRegisterPy "
     try :
        
print   " open HKEY_CURRENT_USER key=%s " % (regpath)
        reg 
=  OpenKey(HKEY_CURRENT_USER, regpath)
        
# reg = OpenKey(HKEY_LOCAL_MACHINE, regpath)
     except  EnvironmentError:  
        
print   " *** Python not registered?! "
        
return
    
try :
       DeleteKey(reg, installkey)
       DeleteKey(reg, pythonkey)
       DeleteKey(HKEY_LOCAL_MACHINE, regpath)
    
except :
       
print   " *** Unable to un-register! "
    
else :
       
print   " --- Python " , version,  " is no longer registered! "             

if   __name__   ==   " __main__ " :  
    RegisterPy()


其实手动在注册表里 操作就可以了。