"目录号: HY-14658
Others-
Thalidomide能抑制由bFGF或VEGF诱导的体内血管生成。
Others
相关产品
SBE-β-CD-MPTP hydrochloride-Cyclosporin A-Etomoxir-Auranofin-GKT137831-Ceruletide-Acetylcysteine-JC-1-BPTES-Brassinolide-FCCP-IPTG-MTT-RSL3 1S,3R--
生物活性
Description
Thalidomide can directly inhibit angiogenesis induced by bFGF or VEGF in vivo.IC50 value:Target:Thalidomide was commonly used therapeutically in the late 1950's; however, it was withdrawn from the market when it was discovered to cause birth defects. More recent research has found Thalidomide to affect key biochemical pathways yielding antiangiogenic and immunomodulatory activities. This compound has been shown to: selectively inhibit tumor necrosis factor-alpha (TNF alpha) biosynthesis and basic fibroblast growth factor (bFGF)-induced angiogenesis, induce apoptosis in human monocytes via a cytochrome c-dependent pathway, and to inhibit HIV-1 replication in a monocytoid (U1) line. These new found uses make Thalidomide an extremely valuable research tool.
Clinical Trial
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Celgene Corporation
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University of Roma La Sapienza
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Medical University of Vienna
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Lymphoma, Large B-Cell, Diffuse
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Shanghai Jiao Tong University School of Medicine
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M.D. Anderson Cancer Center-Celgene
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Fudan University
Hepatocellular Carcinoma
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University of North Carolina, Chapel Hill-Celgene Corporation
Endometriosis
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National Taiwan University Hospital
Hepatocellular Carcinoma
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Dartmouth-Hitchcock Medical Center-Celgene Corporation
Amyotrophic Lateral Sclerosis-ALS
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Multiple Myeloma
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University of Arkansas
Multiple Myeloma
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Ankylosing Spondylitis
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National Cancer Institute (NCI)
Recurrent Grade 1 Follicular Lymphoma-Recurrent Grade 2 Follicular Lymphoma-Recurrent Grade 3 Follicular Lymphoma-Recurrent Small Lymphocytic Lymphoma
July 2001
Phase 2
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University of Arkansas-Celgene Corporation
Waldenstrom Macroglobulinemia
January 1999
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Assistance Publique - Hôpitaux de Paris
Sarcoidosis
February 2005
Phase 3
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Memorial Sloan Kettering Cancer Center-Incyte Corporation-Celgene-M.D. Anderson Cancer Center
Myelofibrosis
February 27, 2017
Phase 2
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Zhejiang Cancer Hospital
Metastatic Breast Cancer
October 2015
Phase 2
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Shandong University-The Affiliated Hospital of the Chinese Academy of Military Medical Sciences-Anhui Medical University-The First Affiliated Hospital of Dalian Medical University-Shenzhen Second People's Hospital
Immune Thrombocytopenia
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Phase 2
NCT00038246
M.D. Anderson Cancer Center-Celgene Corporation
Prostate Cancer
October 2000
Phase 1-Phase 2
NCT01551641
Changzhou No.2 People's Hospital
Esophageal Cancer
January 2012
Phase 2
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IRCCS Burlo Garofolo-Ospedale Meyer-Pediatric Gastroenterology Unit, IRCCS Gaslini, Genoa.-Vittore Buzzi Children's Hospital-University of Pisa-University of Messina-Università degli Studi di Brescia-University of Trieste
Inflammatory Bowel Diseases-Crohn's Disease-Ulcerative Colitis
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The Cleveland Clinic-Celgene Corporation
Gastrointestinal Hemorrhage-Portal Hypertension
May 2006
Phase 3
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Case Comprehensive Cancer Center-National Cancer Institute (NCI)
Cancer
July 2002
Phase 1
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First Affiliated Hospital, Sun Yat-Sen University
Crohn's Disease
January 2013
Phase 2
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Hackensack University Medical Center-Millennium Pharmaceuticals, Inc.
Multiple Myeloma
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Phase 1-Phase 2
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Norwegian University of Science and Technology-The Research Council of Norway-Nordic Myeloma Study Group, Germany
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Centre Hospitalier Universitaire, Amiens
Non Neoplastic Condition-Precancerous Condition
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Phase 2
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Wake Forest University-Wake Forest University Health Sciences
Psoriasis, Plaque-type
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Celgene Corporation-Celgene
Multiple Myeloma
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National Cancer Institute (NCI)