Enzo丨艾美捷Enzo LY 171883解决方案

艾美捷Enzo LY 171883:选择性口服白三烯D4拮抗剂。已证明与过氧化物酶体增殖物激活受体(PPARγ)的γ-亚型结合。

艾美捷Enzo LY 171883基本参数:

替代名称:Tomelukast

配方:C16H22N4O3

兆瓦:318.4

CAS:88107-10-2

纯度:≥90%(高效液相色谱)

外观:白色固体。

熔点:117-119°C

溶解度:可溶于DMSO(25mg/ml)、100%乙醇(25mg/ml)或二甲基甲酰胺。也可溶于0.5M碳酸氢钠水溶液。

长期储存:环境

用途/稳定性:有机储备溶液在-20°C下储存至少六个月。

RUO-仅供研究使用

Enzo丨艾美捷Enzo LY 171883解决方案_第1张图片

艾美捷Enzo LY 171883文献参考:

NF-κB Signaling Negatively Regulates Osteoblast Dedifferentiation during Zebrafish Bone Regeneration: R. Mishra, et al.; Dev. Cell 52, 167 (2020), Application(s): Screening on Juvenile and adult zebrafish, Abstract;

15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma: B.M. Forman, et al.; Cell 83, 803 (1995), Abstract;

Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor: P. Tontonoz, et al.; Cell 79, 1147 (1994), Abstract;

Formation of sulphidopeptide-leukotrienes by cell-cell interaction causes coronary vasoconstriction in isolated, cell-perfused heart of rabbit: A. Sala, et al.; Br. J. Pharmacol. 110, 1206 (1993), Abstract;

In vitro pharmacology of ICI 198,615: a novel, potent and selective peptide leukotriene antagonist: D.W. Snyder, et al.; J. Pharmacol. Exp. Ther. 243, 548 (1987), Abstract;

LY171883, 1-less than 2-hydroxy-3-propyl-4-less than 4-(1H-tetrazol-5-yl) butoxy greater than phenyl greater than ethanone, an orally active leukotriene D4 antagonist: J.H. Fleisch, et al.; J. Pharmacol. Exp. Ther. 233, 148 (1985), Abstract;

 

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