Enzo丨艾美捷Enzo Fenofibrate解决方案

艾美捷Enzo Fenofibrate是低脂化合物。PPARα（过氧化物酶体增殖物激活受体α）激动剂（小鼠EC50=18µM，人PPARαEC50=30µM）。也与PPARγ结合，但亲和力至少低10倍，在PPARδ（EC50=100µM）下不活跃。

艾美捷Enzo  Fenofibrate基本参数：

替代名称：2-[4-（4-氯苯甲酰基）苯氧基]-2-甲基丙酸1-甲基乙酯

配方：C20H21ClO4

CAS:49562-28-9

RTECS:UA2453400

纯度：≥98%（GC）

外观：白色至灰白色结晶固体。

溶解度：可溶于丙酮、乙醚、DMSO或二甲基甲酰胺；微溶于100%乙醇或甲醇；不溶于水。

运输：环境

长期储存：-20°C

RUO-仅供研究使用

艾美捷Enzo Fenofibrate文献参考：

Fenofibrate simultaneously induces hepatic fatty acid oxidation, synthesis and elongation in mice: M.H. Oosterveer, et al.; J. Biol. Chem. 284, 34036 (2009), Abstract;

PPARalpha agonist fenofibrate suppresses tumor growth through direct and indirect angiogenesis inhibition: D. Panigrahy, et al.; PNAS 105, 985 (2008), Abstract; Full Text

Effects of chronic treatment with statins and fenofibrate on rat skeletal muscle: a biochemical, histological and electrophysiological study: S. Pierno, et al.; Br. J. Pharmacol. 149, 909 (2006), Abstract; Full Text

In vitro and in vivo effects of the PPAR-alpha agonists fenofibrate and retinoic acid in endometrial cancer: S.A. Saidi, et al.; Mol. Cancer 5, 13 (2006), Abstract; Full Text

Fenofibrate protects lipoproteins from lipid peroxidation: synergistic interaction with alpha-tocopherol: E. Chaput, et al.; Lipids 34, 497 (1999), Abstract;

Inhibition of membrane-bound hepatic 3 hydroxy-3 methyl glutaryl CoA reductase as the consequence of altered membrane fluidity: E. Wulfert, et al.; Artery 9, 120 (1981), Abstract;

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