复现一篇高分(IF = 11.274)孟德尔随机化分析文章-day1

Title: Association between Human Blood Metabolome and the Risk of Alzheimer's Disease

Link: https://onlinelibrary.wiley.com/doi/10.1002/ana.26464

Journal: Annals of Neurology
Impact factor: 11.274

Day 1. 整理数据来源

Exposure: 3 mQTL (metabolite) datasets

在 IEU OpenGWAS project 网站 https://gwas.mrcieu.ac.uk/datasets/ （met-a，met-c，met-d三个数据集）
数据来源：
met-a：Human blood metabolites analysed by Shin et al 2014，452个metabolites
met-c：Circulating metabolites analysed by Kettunen et al 2016，123个metabolites
met-d：Metabolic biomarkers in the UK Biobank measured by Nightingale Health 2020，249个metabolites

Outcome: Alzheimer GWAS summary:

数据来源：
https://www.niagads.org/igap-rv-summary-stats-kunkle-p-value-data
Kunkle_etal_Stage1_results.txt Stage 1 （P-Value Data TUESDAY, FEBRUARY 26, 2019）