Mutant IDH1 inhibitor

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Metabolic Enzyme/Protease-

Mutant IDH1 inhibitor ???????????????????????????IDH1 R132H???????????????IC50????????? 72 nM???

Isocitrate Dehydrogenase (IDH)

相关产品

Enasidenib-AGI-5198-Ivosidenib-AGI-6780-Mutant IDH1-IN-1-Mutant IDH1-IN-2-GSK864-

生物活性

Description

Mutant IDH1 inhibitor is a potent mutantIDH1 R132Hinhibitor withIC50of < 72 nM.

IC50& Target

IC50: < 72 nM (mutant IDH1 R132H)

In Vitro

Mutant IDH1 inhibitor is a potent IDH1 R132H inhibitor, and used for the treatment of diseases or disorders associated with such mutant IDH proteins including, but not limited to, cell-proliferation disorders, such as cancer[1].

References

[1].3-Pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant IDH and their preparation. Patent WO 2013046136 A1 20130404